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Protein

Quinolinate synthase

Gene

EE66_07745

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.SAAS annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.SAAS annotation

Cofactori

[4Fe-4S] clusterSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA), Quinolinate synthase (AC783_03365), Quinolinate synthase (BGL62_06235), Quinolinate synthase (HPMKF3_0043), Quinolinate synthase (BGL73_04555), Quinolinate synthase (BGL58_03270), Quinolinate synthase (BB463_00520), Quinolinate synthase (BGL85_03255), Quinolinate synthase (AA971_06325), Quinolinate synthase (BB390_03560), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB425_05080), Quinolinate synthase (BB399_06925), Quinolinate synthase (AA977_07105), Quinolinate synthase (BB392_04940), Quinolinate synthase (AEY53_04695), Quinolinate synthase (BB458_04130), Quinolinate synthase (AC786_05590), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (HPF94_0043), Quinolinate synthase (BB403_04690), Quinolinate synthase (HPF55_0045), Quinolinate synthase (BB428_03850), Quinolinate synthase (AK968_04145), Quinolinate synthase (BGL71_06650), Quinolinate synthase A (nadA), Quinolinate synthase (AEY55_07010), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (AM496_03720), Quinolinate synthase (BZK19_04595), Quinolinate synthase A (nadA), Quinolinate synthase (HPF210_0043), Quinolinate synthase A (nadA), Quinolinate synthase (AA974_06160), Quinolinate synthase A (nadA), Quinolinate synthase (BB395_04085), Quinolinate synthase (BB445_06880), Quinolinate synthase (HPF38_0050), Quinolinate synthase (BGL77_00455), Quinolinate synthase (HPF17_0045), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB464_04980), Quinolinate synthase (BB401_04235), Quinolinate synthase (BB388_00285), Quinolinate synthase (HPF51_0044), Quinolinate synthase (BGL83_04195), Quinolinate synthase (HPF20_0047), Quinolinate synthase (ACM24_00465), Quinolinate synthase (BB475_02850), Quinolinate synthase (BB430_03035), Quinolinate synthase (BB394_06350), Quinolinate synthase (HPMKM6_0049), Quinolinate synthase (HPF78_0049), Quinolinate synthase (BB386_06910), Quinolinate synthase (BB397_07615), Quinolinate synthase A (nadA), Quinolinate synthase (BB449_05335), Quinolinate synthase A (nadA), Quinolinate synthase (ACM25_04670), Quinolinate synthase (AA973_06160), Quinolinate synthase A (nadA), Quinolinate synthase (BGL55_07905), Quinolinate synthase (BGL67_05465), Quinolinate synthase (BGL81_03250), Quinolinate synthase (AC782_02175), Quinolinate synthase (ACM29_05840), Quinolinate synthase (BB431_05820), Quinolinate synthase (BZK20_00770), Quinolinate synthase A (nadA), Quinolinate synthase (BZK21_01005), Quinolinate synthase (ACM26_07720), Quinolinate synthase A (nadA), Quinolinate synthase (BB482_06490), Quinolinate synthase (AEY52_07200), Quinolinate synthase (HPY499_01385), Quinolinate synthase (BB461_05325), Quinolinate synthase (BZK27_01705), Quinolinate synthase (AA976_06880), Quinolinate synthase (BB483_07670), Quinolinate synthase A (nadA), Quinolinate synthase (HPF209_0046), Quinolinate synthase (ACM32_02395), Quinolinate synthase (ACM37_05900), Quinolinate synthase (AB991_05550), Quinolinate synthase (HPMKM1_0044), Quinolinate synthase A (nadA), Quinolinate synthase (HPY228_06205), Quinolinate synthase (BB423_05755), Quinolinate synthase (HPMKF10_0090), Quinolinate synthase (BIZ48_04360), Quinolinate synthase (AB891_06965), Quinolinate synthase (BB409_06655), Quinolinate synthase A (nadA), Quinolinate synthase (ACM28_02565), Quinolinate synthase (BGL76_00185), Quinolinate synthase A (nadA), Quinolinate synthase (EE66_07745), Quinolinate synthase (ACM31_06075), Quinolinate synthase A (nadA), Quinolinate synthase (BGL60_02890), Quinolinate synthase (BB448_06675), Quinolinate synthase (JM68_01315), Quinolinate synthase A (nadA), Quinolinate synthase (BB447_01570), Quinolinate synthase (BGL74_00845), Quinolinate synthase (BB389_07500), Quinolinate synthase (AC784_04740), Quinolinate synthase (BB434_03360), Quinolinate synthase (HPY1846_02420), Quinolinate synthase (BZK26_07335), Quinolinate synthase (BB436_03185), Quinolinate synthase (BGL64_00830), Quinolinate synthase (BB471_07420), Quinolinate synthase (HPMKM5_0045), Quinolinate synthase (BGL59_02580), Quinolinate synthase (BGL82_01035), Quinolinate synthase (BB415_07315), Quinolinate synthase (ACM23_00975), Quinolinate synthase (EG63_06695), Quinolinate synthase (BB400_07225), Quinolinate synthase (HPF63_0047), Quinolinate synthase (HPF75_0049), Quinolinate synthase A (nadA), Quinolinate synthase (BB411_06835), Quinolinate synthase (ACM27_07100), Quinolinate synthase (BB408_07620), Quinolinate synthase (CGC32_07160), Quinolinate synthase (HPY173_04020), Quinolinate synthase (HPF211_0044), Quinolinate synthase (AOD76_0201075), Quinolinate synthase (BB459_06300), Quinolinate synthase (BB451_03970), Quinolinate synthase (HPY655_06365), Quinolinate synthase A (nadA), Quinolinate synthase (BB398_07655), Quinolinate synthase (BB414_04340), Quinolinate synthase (BB404_07050), Quinolinate synthase (BB413_07120), Quinolinate synthase (BB407_01115), Quinolinate synthase (BZK18_04270), Quinolinate synthase (BGL70_03090), Quinolinate synthase (BHU51_02520), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB433_07695), Quinolinate synthase (HPF72_0043), Quinolinate synthase (BB469_07440), Quinolinate synthase A (nadA), Quinolinate synthase (BB468_06445), Quinolinate synthase (BV499_07240), Quinolinate synthase (HPY1786_06525), Quinolinate synthase (BB384_07435), Quinolinate synthase (BGL78_02880), Quinolinate synthase (BGL87_02485), Quinolinate synthase (BB396_07710), Quinolinate synthase (BGL75_01500), Quinolinate synthase A (nadA), Quinolinate synthase (BZK22_08035), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (AV921_0207375), Quinolinate synthase A (nadA), Quinolinate synthase (nadA), Quinolinate synthase (BB454_05770), Quinolinate synthase (AOD77_0202490)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processPyridine nucleotide biosynthesisSAAS annotation
Ligand4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthaseSAAS annotation (EC:2.5.1.72SAAS annotation)
Gene namesi
ORF Names:EE66_07745Imported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000077641 Componenti: Chromosome

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR003473. NadA.
IPR036094. NadA_sf.
PANTHERiPTHR30573. PTHR30573. 1 hit.
PfamiView protein in Pfam
PF02445. NadA. 1 hit.
SUPFAMiSSF142754. SSF142754. 1 hit.
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1A9H2X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTGNDLKTS ILELLRDLDA LLVAHFYQKD EIVELAHYTG DSLELAKIAS
60 70 80 90 100
QSDKNLIVFC GVHFMGESVK ALAFNKQVIM PKLSCCSMAR MIDSHYYDRS
110 120 130 140 150
VHLLKEYGVK EFYPITYINS NAEVKAKVAK DGGVVCTSRN ASKIFNHALK
160 170 180 190 200
QNKKIFFLPD KCLGENLALE NGLKSAILGA NSQEEIKNAD VVCYNGFCSV
210 220 230 240 250
HQLFKLEDIE FYRQKYPDIL IAVHPECEPS VVQNADFSGS TSQIIEFVES
260 270 280 290 300
LNPHQKVAIG TESNLVNRLK AKRNHQNTFI LSSTLALCPT MNETTLKDLF
310 320 330
EVLKAYKNHR AFNAIELKDE VARLAKLALT KMMELS
Length:336
Mass (Da):37,732
Last modified:October 5, 2016 - v1
Checksum:iBA0120831B4AB090
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011483 Genomic DNA. Translation: ANH44726.1.
RefSeqiWP_064431547.1. NZ_CP011483.1.

Genome annotation databases

EnsemblBacteriaiANH44726; ANH44726; EE66_07745.
PATRICifig|210.2438.peg.1625.

Similar proteinsi

Entry informationi

Entry nameiA0A1A9H2X2_HELPX
AccessioniPrimary (citable) accession number: A0A1A9H2X2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: October 25, 2017
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported