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Protein

Tyrosine-protein kinase receptor

Gene

NTRK2A

Organism
Nothobranchius furzeri (Turquoise killifish)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:NTRK2AImported
OrganismiNothobranchius furzeri (Turquoise killifish)Imported
Taxonomic identifieri105023 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesNothobranchiidaeNothobranchius

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei422 – 445HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_500837952239 – 815Tyrosine-protein kinase receptorSequence analysisAdd BLAST777

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 289Ig-likeInterPro annotationAdd BLAST81
Domaini529 – 800Protein kinaseInterPro annotationAdd BLAST272

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KOiK04360

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1A8U6W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASRPGIWA LSVPGRGSGS WQCFWWWAVA LGVTVSSGDP WMTVEACPSP
60 70 80 90 100
CSCSSTRISC VDPERGINAF PVLQSEAEME NITDIYIANQ SSFSSINDKD
110 120 130 140 150
LHYYKNLRNL TVTNSRLTYV SKLAFQNNIK LQYLNLKDNN LSSLSWRIFK
160 170 180 190 200
HLNISYLILS GNPLHCSCEN MWIKLWLAEE ADTQELRCIE DGGARKLLSK
210 220 230 240 250
LTPPNCEVPT ATLSPSKATV KEGENVELTC TTFGVPSPEL IWNMALVSNY
260 270 280 290 300
VIETSGQISV LRLSNLSSLD HNRKISCTAG NIVGERESSL LLDILFPPKI
310 320 330 340 350
TKLSDAIPDH HWCIPFSVAA NPQPYFQWYR DDEKVTEGDY IMTMIHDVTE
360 370 380 390 400
REYHGCLQLD SPTHINNGQY TLVVTNEYGS DQKMVSAHFM LQPWGDTDTP
410 420 430 440 450
IYYGGDEIPT DTTPLEPPED RVAVYVVVGI AAVAFTGFLL MLVILKFGGN
460 470 480 490 500
SKFGIKGPSS VISNDDDSAS PLHHVSNGSN TPSSSEMGPD AVIIGMTKIP
510 520 530 540 550
VIENPQYFRS TNSLLKTNTF VQHIKRHNIV LKRELGEGAF GKVFLAECYN
560 570 580 590 600
LSPDQDKILV AVKTLKEASE NARKDFHREA ELLTNLQHEH IVTFYGVCVE
610 620 630 640 650
SDPLIMVFEY MKHGDLNKFL RAHGPDAVLM AEGQTTRPVE LTQSQMLHIA
660 670 680 690 700
QQIASGMVYL ASQHFVHRDL ATRNCLVGEN LLVKIGDFGM SRDVYSTDYY
710 720 730 740 750
RVGGHTMLPI RWMPPESIMY RKFTTESDVW SLGVVLWEIF TYGKQPWYQL
760 770 780 790 800
SNNEVIECIT QGRVLQRPRT CPKEVYDLML GCWQREPHMR LNIKEIHTLL
810
LNLAKASPVY LDILG
Length:815
Mass (Da):91,585
Last modified:October 5, 2016 - v1
Checksum:iE4796B67C30A4230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HAEJ01003597 Transcribed RNA Translation: SBS44054.1
RefSeqiXP_015828237.1, XM_015972751.1

Genome annotation databases

GeneIDi107394032
KEGGinfu:107394032

Similar proteinsi

Entry informationi

Entry nameiA0A1A8U6W6_NOTFU
AccessioniPrimary (citable) accession number: A0A1A8U6W6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: February 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health