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Protein

Acetaldehyde dehydrogenase

Gene

A5698_01290

Organism
Mycobacterium sp. E136
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126Acyl-thioester intermediateUniRule annotation1
Binding sitei280NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADUniRule annotation4
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processAromatic hydrocarbons catabolismUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotationSAAS annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
ORF Names:A5698_01290Imported
OrganismiMycobacterium sp. E136Imported
Taxonomic identifieri1834125 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000092008 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 118Semialdhyde_dhInterPro annotationAdd BLAST114

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1A2M7J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKTSVAIVG SGNISTDLLY KLLRSEWLEP RWMIGIDPES EGLARARKLG
60 70 80 90 100
LETSHEGVDW LLAQSEKPDM VFEATSAYVH RDAAPKYAEA GIRAIDLTPA
110 120 130 140 150
AVGPGVIPPA NLREHLDAPN VNMVTCGGQA TIPIVYAVSR ALVDNGGVPY
160 170 180 190 200
AEIVASVSSA SAGPGTRANI DEFTKTTSNG VEVIGGAQRG KAIIILNPAE
210 220 230 240 250
PPMIMRDTIF CAIPEDADHD AITQSIRDVV AEVQTYVPGY RLLNDPQFDE
260 270 280 290 300
PSVVNGGNHV VTTFIEVEGA GDYLPPYAGN LDIMTAAAAK VGEEIAKEKA
310
GASLASSKGG QA
Length:312
Mass (Da):32,831
Last modified:October 5, 2016 - v1
Checksum:iC55BA0FBAE8CA10E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LZJE01000068 Genomic DNA Translation: OBG98375.1
RefSeqiWP_068294072.1, NZ_LZJE01000068.1

Genome annotation databases

EnsemblBacteriaiOBG98375; OBG98375; A5698_01290

Similar proteinsi

Entry informationi

Entry nameiA0A1A2M7J5_9MYCO
AccessioniPrimary (citable) accession number: A0A1A2M7J5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: October 25, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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