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Protein

NADPH--cytochrome P450 reductase

Gene

cprA

Organism
Valsa mali
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotationNote: Binds 1 FAD per monomer.UniRule annotation
  • FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei200FMNUniRule annotation1
Binding sitei292NADPUniRule annotation1
Binding sitei549NADPUniRule annotation1
Binding sitei653NADPUniRule annotation1
Binding sitei680FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 76FMNUniRule annotation6
Nucleotide bindingi122 – 125FMNUniRule annotation4
Nucleotide bindingi165 – 174FMNUniRule annotation10
Nucleotide bindingi448 – 451FADUniRule annotation4
Nucleotide bindingi466 – 468FADUniRule annotation3
Nucleotide bindingi483 – 486FADUniRule annotation4
Nucleotide bindingi611 – 612NADPUniRule annotation2
Nucleotide bindingi617 – 621NADPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism
LigandFADUniRule annotation, Flavoprotein, FMNUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)
Short name:
CPRUniRule annotation
Short name:
P450RUniRule annotation
Gene namesi
Name:cprAUniRule annotation
ORF Names:VM1G_04212Imported
OrganismiValsa maliImported
Taxonomic identifieri105487 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeDiaporthalesValsaceaeValsa
Proteomesi
  • UP000078559 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 24HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Cell membraneUniRule annotation, Endoplasmic reticulumUniRule annotation, Membrane, Mitochondrion, Mitochondrion outer membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 217Flavodoxin-likeInterPro annotationAdd BLAST153
Domaini273 – 521FAD-binding FR-typeInterPro annotationAdd BLAST249

Sequence similaritiesi

Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
HAMAPiMF_03212. NCPR. 1 hit.
InterProiView protein in InterPro
IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin-like.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like_sf.
IPR023173. NADPH_Cyt_P450_Rdtase_alpha.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
PfamiView protein in Pfam
PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PIRSFiPIRSF000208. P450R. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiView protein in PROSITE
PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A194VYB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELDTLDVI VLAAILLGTV AYFTKGKYWG VAKDPYANSF ANGNAAKAGK
60 70 80 90 100
TRNIVEKMEE SGKNCIIFYG SQTGTAEDYA SRLAKEGKSR FGLETMVADL
110 120 130 140 150
EDYDYENLDT IPSDKIVMFV LATYGEGEPT DNAVDFYEFI TAEDVSFSES
160 170 180 190 200
NDPPLGNLNY VAFGLGNNTY EHYNSMVRNV NASLEKLGAH KIGEAGEGDD
210 220 230 240 250
GAGTMEEDFL AWKEPMWTAL ASKMGLEERE AVYEPIFSII DREGLTKDSH
260 270 280 290 300
EVYLGEPNKM HLEGTSKGPF NAHNPYIAPI AESYELFSVK DRNCLHMEVD
310 320 330 340 350
ISGSNLNYQT GDHIAVWPTN PGEEVDRLMN ILGLSEKRDH VISVKALEPT
360 370 380 390 400
AKVPFPTPTT FDAIVRYHME ICAPVSRQFL ATLAAFAPDE ESKAEMTRLG
410 420 430 440 450
GDRDYFYEKV SAQHLSIARV LEAVGKGQQW NNIPFSAFIE GLTKLQPRYY
460 470 480 490 500
SISSSSLVQP KKISITAVVE AQTLPGRSDM FRGVTTNYLL ALKQKQNGDP
510 520 530 540 550
NPEPFGLTYE ITGPRNKYDG IHVPVHVRHS NFKLPSDPSK PIIMIGPGTG
560 570 580 590 600
VAPFRGFIQE RAKEAENGES IGKTVLFFGC RKRDEDFMYA SEWEQYKQVM
610 620 630 640 650
GDKFEMHNAF SREGPEKVYV QHLLKQQGKE INELLEKKAY FYVCGDAANM
660 670 680
AREVNAVLAQ IIAEHRGVSE AKAEEIEDVW S
Length:681
Mass (Da):75,867
Last modified:October 5, 2016 - v1
Checksum:iCC53070CF061B1E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003101 Genomic DNA. Translation: KUI68800.1.

Genome annotation databases

EnsemblFungiiKUI68800; KUI68800; VM1G_04212.

Similar proteinsi

Entry informationi

Entry nameiA0A194VYB8_9PEZI
AccessioniPrimary (citable) accession number: A0A194VYB8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: March 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported