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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Rhizobium phaseoli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotationSAAS annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99MagnesiumUniRule annotation1
Binding sitei102XanthineUniRule annotation1
Binding sitei145Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPurine salvageUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotationImported
ORF Names:AMC80_CH01780Imported, AMC87_CH01800Imported
OrganismiRhizobium phaseoliImported
Taxonomic identifieri396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000078601 Componenti: Chromosome
  • UP000078566 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A192P4S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 153PribosyltranInterPro annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 425-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni102 – 1065-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00769.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_01903. XGPRT. 1 hit.
InterProiView protein in InterPro
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
PANTHERiPTHR39563. PTHR39563. 1 hit.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A192P4S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPDKAFPV SWDQFHRDAR ALAWRLAGLD QTFKAIVCIT RGGLVPAAII
60 70 80 90 100
SRELNIRLIE TVCIASYHDY VNQGDMVLLK GIAPELAENG GEGVLVVDDL
110 120 130 140 150
TDTGKTAAQV RTMLPKAHFA CVYAKPKGVP TVDTFITEVS QDTWIYFPWD
160
MGFTYQEPIA KGAR
Length:164
Mass (Da):18,116
Last modified:October 5, 2016 - v1
Checksum:i6633F9EEE570A173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013537 Genomic DNA. Translation: ANL46494.1.
CP013574 Genomic DNA. Translation: ANL91071.1.
RefSeqiWP_010025058.1. NZ_NWSP01000018.1.

Genome annotation databases

EnsemblBacteriaiANL46494; ANL46494; AMC87_CH01800.
ANL91071; ANL91071; AMC80_CH01780.
GeneIDi24300151.
KEGGirpha:AMC79_CH01880.
PATRICifig|396.10.peg.1892.

Similar proteinsi

Entry informationi

Entry nameiA0A192P4S5_9RHIZ
AccessioniPrimary (citable) accession number: A0A192P4S5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: February 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported