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Protein

Adenosylhomocysteinase

Gene

AXX17_At4g15900

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (HOG1), Adenosylhomocysteinase, Adenosylhomocysteinase (HOG1), Adenosylhomocysteinase 2 (SAHH2), Adenosylhomocysteinase 1 (SAHH1), Adenosylhomocysteinase (HOG1), Adenosylhomocysteinase (AXX17_At4g15900), Adenosylhomocysteinase (AXX17_At3g25710), Adenosylhomocysteinase (HOG1)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64SubstrateUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Binding sitei205SubstrateUniRule annotation1
Binding sitei235SubstrateUniRule annotation1
Binding sitei239SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:AXX17_At4g15900Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000078284 Componenti: Chromosome 4

Expressioni

Gene expression databases

ExpressionAtlasiA0A178UZR5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A178UZR5.
SMRiA0A178UZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini240 – 403AdoHcyase_NADInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

KOiK01251.
OMAiFWHKAVA.
PhylomeDBiA0A178UZR5.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A178UZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLVEKTSS GREYKVKDMS QADFGRLELE LAEVEMPGLM ACRTEFGPSQ
60 70 80 90 100
PFKGARITGS LHMTIQTAVL IETLTALGAE VRWCSCNIFS TQDHAAAAIA
110 120 130 140 150
RDSAAVFAWK GETLQEYWWC TERALDWGPG GGPDLIVDDG GDATLLIHEG
160 170 180 190 200
VKAEEIFEKT GQVPDPTSTD NPEFQIVLSI IKEGLQVDPK KYHKMKERLV
210 220 230 240 250
GVSEETTTGV KRLYQMQQNG TLLFPAINVN DSVTKSKFDN LYGCRHSLPD
260 270 280 290 300
GLMRATDVMI AGKVAVICGY GDVGKGCAAA MKTAGARVIV TEIDPICALQ
310 320 330 340 350
ALMEGLQVLT LEDVVSEADI FVTTTGNKDI IMVDHMRKMK NNAIVCNIGH
360 370 380 390 400
FDNEIDMLGL ETYPGVKRIT IKPQTDRWVF PETKAGIIVL AEGRLMNLGC
410 420 430 440 450
ATGHPSFVMS CSFTNQVIAQ LELWNEKASG KYEKKVYVLP KHLDEKVALL
460 470 480
HLGKLGARLT KLSKDQSDYV SIPIEGPYKP PHYRY
Length:485
Mass (Da):53,379
Last modified:September 7, 2016 - v1
Checksum:i1113270A0F46C86C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LUHQ01000004 Genomic DNA. Translation: OAO98322.1.
RefSeqiNP_193130.1. NM_117468.3.
UniGeneiAt.24056.
At.24845.
At.71956.
At.74987.
At.74988.

Genome annotation databases

EnsemblPlantsiAT4G13940.1; AT4G13940.1; AT4G13940.
GeneIDi827028.
GrameneiAT4G13940.1; AT4G13940.1; AT4G13940.
KEGGiath:AT4G13940.

Similar proteinsi

Entry informationi

Entry nameiA0A178UZR5_ARATH
AccessioniPrimary (citable) accession number: A0A178UZR5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: November 22, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported