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Protein

Pyruvate kinase

Gene

At5g56350

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (At5g63680), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (At3g25960), Pyruvate kinase (F1I16_60), Pyruvate kinase (MBK5.16), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At5g08570), Pyruvate kinase (At3g52990), Pyruvate kinase (At5g56350), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase (At2g36580), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (At2g36580), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:At5g56350Imported, AXX17_At5g55530Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000078284 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G56350.
TAIRilocus:2161068. AT5G56350.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

ExpressionAtlasiA0A178UH02. baseline and differential.

Structurei

3D structure databases

SMRiA0A178UH02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 351PKInterPro annotationAdd BLAST343
Domaini368 – 494PK_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

KOiK00873.

Family and domain databases

CDDicd00288. Pyruvate_Kinase. 1 hit.
Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom_sf.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR036918. Pyrv_Knase_C_sf.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A178UH02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMIEQRPKT KIVCTLGPAS RSVPMVEKLL RAGMNVARFN FSHGSHEYHQ
60 70 80 90 100
ETLDNLHQAM LNTGILCAVM LDTKGPEIRT GFLKDGKPIQ LKQGQEITIS
110 120 130 140 150
TDYDLKGDEN TICMSYKKLA VDVNPGMVIL CADGTISLLV LSCDKENGTV
160 170 180 190 200
RCRCENSAML GERKNVNLPG VVVDLPTLTE KDKEDIMQWG VPNQIDMIAL
210 220 230 240 250
SFVRKGSDLV QVRKLLGKHA KNILLMSKVE NQEGVANFDD ILVNSDAFMI
260 270 280 290 300
ARGDLGMEIP IEKIFLAQKV MIYKCNIQGK PVVTATQMLE SMIKSPRPTR
310 320 330 340 350
AEATDVANAV LDGTDCVMLS GETAAGAYPE LAVRTMAKIC VEAESTLDYG
360 370 380 390 400
DVFKRIMLYS PVPMSPLESL ASSAVRTANS ARATLIMVLT RGGSTARLVA
410 420 430 440 450
KYRPGMPILS VVVPEIKTDF FDWSCSDESP ARHSLIFRGL IPVLYAGSAR
460 470 480 490
ASHDESTEEA IEFATQYGKE KELCKTGDSV VALLRVGNAS VIKILTVK
Length:498
Mass (Da):54,411
Last modified:April 12, 2017 - v1
Checksum:i90C1374AC09079B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LUHQ01000005 Genomic DNA. Translation: OAO93058.1.
RefSeqiNP_200446.1. NM_125018.3.
UniGeneiAt.20243.
At.74779.

Genome annotation databases

EnsemblPlantsiAT5G56350.1; AT5G56350.1; AT5G56350.
GeneIDi835735.
GrameneiAT5G56350.1; AT5G56350.1; AT5G56350.
KEGGiath:AT5G56350.

Similar proteinsi

Entry informationi

Entry nameiA0A178UH02_ARATH
AccessioniPrimary (citable) accession number: A0A178UH02
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: November 22, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported