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Protein

Pyruvate kinase

Gene

AXX17_At5g51800

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At5g63250), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (F1I16_60), Pyruvate kinase (At3g25960), Pyruvate kinase (MBK5.16), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (AXX17_At5g08490), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At5g55530), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (At2g36580), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (AXX17_At2g33300), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:AXX17_At5g51800Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000078284 Componenti: Chromosome 5

Expressioni

Gene expression databases

ExpressionAtlasiA0A178U9G2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A178U9G2.
SMRiA0A178U9G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 446PKInterPro annotationAdd BLAST337
Domaini467 – 560PK_CInterPro annotationAdd BLAST94

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

KOiK00873.
OMAiAFHATMM.
PhylomeDBiA0A178U9G2.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom_sf.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR036918. Pyrv_Knase_C_sf.
IPR015806. Pyrv_Knase_insert_dom_sf.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A178U9G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVVATRSI QGSMLSPNGG SVSTRSEKLL KPASFAVKVL GNEAKRSGRV
60 70 80 90 100
SVRSRRVVDT TVRSARVETE VIPVSPEDVP NREEQLERLL EMQQFGDTSV
110 120 130 140 150
GMWSKPTVRR KTKIVCTVGP STNTREMIWK LAEAGMNVAR MNMSHGDHAS
160 170 180 190 200
HKKVIDLVKE YNAQTKDNTI AIMLDTKGPE VRSGDLPQPI MLDPGQEFTF
210 220 230 240 250
TIERGVSTPS CVSVNYDDFV NDVEAGDMLL VDGGMMSFMV KSKTKDSVKC
260 270 280 290 300
EVVDGGELKS RRHLNVRGKS ATLPSITEKD WEDIKFGVEN KVDFYAVSFV
310 320 330 340 350
KDAQVVHELK KYLQNSGADI HVIVKIESAD SIPNLHSIIT ASDGAMVARG
360 370 380 390 400
DLGAELPIEE VPILQEEIIN LCRSMGKAVI VATNMLESMI VHPTPTRAEV
410 420 430 440 450
SDIAIAVREG ADAVMLSGET AHGKFPLKAA GVMHTVALRT EATITSGEMP
460 470 480 490 500
PNLGQAFKNH MSEMFAYHAT MMSNTLGTST VVFTRTGFMA ILLSHYRPSG
510 520 530 540 550
TIYAFTNEKK IQQRLALYQG VCPIYMEFTD DAEETFANAL ATLLKQGMVK
560 570
KGEEIAIVQS GTQPIWRSQS THNIQVRKV
Length:579
Mass (Da):63,522
Last modified:September 7, 2016 - v1
Checksum:i9A728605C826B4D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LUHQ01000005 Genomic DNA. Translation: OAO90249.1.
RefSeqiNP_200104.1. NM_124670.3.
UniGeneiAt.20836.

Genome annotation databases

EnsemblPlantsiAT5G52920.1; AT5G52920.1; AT5G52920.
GeneIDi835369.
GrameneiAT5G52920.1; AT5G52920.1; AT5G52920.
KEGGiath:AT5G52920.

Similar proteinsi

Entry informationi

Entry nameiA0A178U9G2_ARATH
AccessioniPrimary (citable) accession number: A0A178U9G2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: February 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported