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Protein

Anthranilate synthase component 1

Gene

trpE

Organism
Chloroflexus islandicus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase component 1UniRule annotation (EC:4.1.3.27UniRule annotation)
Gene namesi
Name:trpEUniRule annotation
ORF Names:A6A03_01145Imported
OrganismiChloroflexus islandicusImported
Taxonomic identifieri1707952 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000078287 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 166Anth_synt_I_NInterPro annotationAdd BLAST139
Domaini232 – 485Chorismate_bindInterPro annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili176 – 196Sequence analysisAdd BLAST21
Coiled coili323 – 343Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the anthranilate synthase component I family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801 ADC_synthase
IPR019999 Anth_synth_I-like
IPR006805 Anth_synth_I_N
IPR005256 Anth_synth_I_PabB
IPR015890 Chorismate_C
PfamiView protein in Pfam
PF04715 Anth_synt_I_N, 1 hit
PF00425 Chorismate_bind, 1 hit
PRINTSiPR00095 ANTSNTHASEI
SUPFAMiSSF56322 SSF56322, 1 hit
TIGRFAMsiTIGR00564 trpE_most, 1 hit

Sequencei

Sequence statusi: Complete.

A0A178MGW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYPTLDQMY DLRRQGNLCP IYREIMADLE TPVSAYLKIA QNGLGFLLES
60 70 80 90 100
VTGGQNVGRY SFIGSDPYMV LRMHDGVAQA THGGYKQTLS YTDPLIVLES
110 120 130 140 150
YLNAYRPIRL PNLPIFVGGA VGYLNYESAR YFERLPVPPV RPYDMPDSWW
160 170 180 190 200
MFVDTLLAFD HVRHKIIVIS HVHLDVEDLA AEYQRAVHRI ETLIARLQKP
210 220 230 240 250
LPPTIGFSLR NYEPHNTPAR VVPNPAVSNR TEAEFKAAVL RAKEYIMAGD
260 270 280 290 300
IFQVQISQRF SKATSADSFT IYRALRTINP SPYMFYIRTG EGDLVGASPE
310 320 330 340 350
MLVQVRDGKV TTRPIAGTRW RGRDAAEDER LAAELLADEK ERAEHLMLVD
360 370 380 390 400
LGRNDLGRIS EPGTVQVPVF MTIEKYSHVQ HIVSEVTGRL RADLKPIDAL
410 420 430 440 450
RACFPAGTVT GAPKIRSMEI IAELEGEQRG VYAGAVGHLG FNGDLDTCIA
460 470 480 490 500
LRTLIVKDGV AYAQAAAGVV ADSTPEYEFN ESCNKAAASL RAIDLAEELQ

AGSPSS
Length:506
Mass (Da):56,197
Last modified:September 7, 2016 - v1
Checksum:i09280E1BC52E3B32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LWQS01000038 Genomic DNA Translation: OAN47377.1
RefSeqiWP_066784545.1, NZ_LWQS01000038.1

Genome annotation databases

EnsemblBacteriaiOAN47377; OAN47377; A6A03_01145

Similar proteinsi

Entry informationi

Entry nameiA0A178MGW5_9CHLR
AccessioniPrimary (citable) accession number: A0A178MGW5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: December 20, 2017
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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