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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Magnetospirillum marisnigri
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotationSAAS annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotationSAAS annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processLipid A biosynthesisUniRule annotationSAAS annotation, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotationSAAS annotation (EC:2.4.1.182UniRule annotationSAAS annotation)
Gene namesi
Name:lpxBUniRule annotation
ORF Names:A6A04_08750Imported
OrganismiMagnetospirillum marisnigriImported
Taxonomic identifieri1285242 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
Proteomesi
  • UP000078428 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

A0A178M5E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRTAPLIYV IAGEPSGDLL GGRLMAALKA RTDGAVRFAG IGGESMRAEG
60 70 80 90 100
LEPLFPMAEL SVMGLVEVLP RLPNILRRIG QTLSDIETKR PDAVLTIDSW
110 120 130 140 150
GFTGRIHKGL KARGSTIPRI HYVAPMVWAW KSGRTKTLAR VLDLLLTLLP
160 170 180 190 200
NEPAWFEKEG LRSVHVGHPV IEGGAGRGDG AAFRARHGLA ADAELLCVLP
210 220 230 240 250
GSRHSETSRL LPAFAETLAL LASRRPGLVA VVPTVETVAE DVTAAARSWP
260 270 280 290 300
LPTIVVRGAA EKHDAFAACS VALAASGTVA LELAMAGLPS VITYKVSKLS
310 320 330 340 350
AFIATRFLGL SLKFVTLVNI LVDQPVMPEL LQDQCRPDRL AAAVEHLLID
360 370 380 390
PAAREAQVAG ARRALEKLGL GGASPSLRAA DTVLAYIGER S
Length:391
Mass (Da):41,470
Last modified:September 7, 2016 - v1
Checksum:i691E43852CBA3223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LWQT01000120 Genomic DNA Translation: OAN43961.1
RefSeqiWP_068495755.1, NZ_LWQT01000120.1

Genome annotation databases

EnsemblBacteriaiOAN43961; OAN43961; A6A04_08750

Similar proteinsi

Entry informationi

Entry nameiA0A178M5E1_9PROT
AccessioniPrimary (citable) accession number: A0A178M5E1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: September 27, 2017
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported