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Protein

Malate dehydrogenase

Gene

mdh

Organism
Sulfitobacter sp. HI0082
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:A3753_03110Imported
OrganismiSulfitobacter sp. HI0082Imported
Taxonomic identifieri1822257 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeSulfitobacter
Proteomesi
  • UP000077444 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 143Ldh_1_NInterPro annotationAdd BLAST139
Domaini147 – 306Ldh_1_CInterPro annotationAdd BLAST160

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A176IFH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPKIALIG AGQIGGTLAH LAALKELGDV VLFDIAEGTP EGKALDIASS
60 70 80 90 100
GPSGKFDATL SGTQDYADIA GADVCIVTAG VARKPGMSRD DLLGINLKVM
110 120 130 140 150
KSVGEGIAKH APDAFVICIT NPLDAMVWAL REFSGLPHNK VCGMAGVLDS
160 170 180 190 200
ARFRHFLATE FNVSMKDVTA FVLGGHGDTM VPLVRYSTVA GIPLPDLVKM
210 220 230 240 250
GWTTQDKLDA IVQRTRDGGA EIVGLLKTGS AFYAPATSAI EMAEAYLKDQ
260 270 280 290 300
KRVLPAAAHV DGAYGLNGFY VGVPTVIGAG GVERVVEISM NKDEQAMFDN
310 320
SVNAVKGLVE ACKGIDESLA
Length:320
Mass (Da):33,389
Last modified:September 7, 2016 - v1
Checksum:i09ECE4D67797793E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LWFW01001547 Genomic DNA. Translation: KZZ24198.1.

Genome annotation databases

EnsemblBacteriaiKZZ24198; KZZ24198; A3753_03110.

Similar proteinsi

Entry informationi

Entry nameiA0A176IFH4_9RHOB
AccessioniPrimary (citable) accession number: A0A176IFH4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: November 22, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported