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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bacillus velezensis
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
ORF Names:BCBMB205_29370Imported
OrganismiBacillus velezensisImported
Taxonomic identifieri492670 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalUniRule annotationAdd BLAST21
Transmembranei84 – 107HelicalUniRule annotationAdd BLAST24
Transmembranei119 – 138HelicalUniRule annotationAdd BLAST20
Transmembranei190 – 211HelicalUniRule annotationAdd BLAST22
Transmembranei223 – 244HelicalUniRule annotationAdd BLAST22
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiView protein in InterPro
IPR003824. UppP.
PANTHERiPTHR30622. PTHR30622. 1 hit.
PfamiView protein in Pfam
PF02673. BacA. 1 hit.
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A172XLZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTAAVLGIV EGLTEYAPVS STGHMIIADD IWLKSGSLMN PEAANSFKVV
60 70 80 90 100
IQLGSILAVA IVFKDRILHL LGLKKNVTRD QQKGYRLTIA QIAVGLVPAA
110 120 130 140 150
VLGFLFEDFI DRYLFSVRTV AYGLIAGAVL MLIADWINKR KETIDTVDRI
160 170 180 190 200
TYKQAFCVGL FQCLALWPGF SRSGSTIAGG VIVGLNHRAA ADFTFIMAIP
210 220 230 240 250
IMAGASLLKL VKYWSSLSYD MIPFFLVGFI CAFVVALLVV KFFLRLINRI
260 270
KLVPFAIYRV ILGIILIMLV R
Length:271
Mass (Da):29,871
Last modified:September 7, 2016 - v1
Checksum:i31A780EF25942B61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014838 Genomic DNA. Translation: ANF37827.1.

Similar proteinsi

Entry informationi

Entry nameiA0A172XLZ1_9BACI
AccessioniPrimary (citable) accession number: A0A172XLZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: September 27, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)