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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium crudilactis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei725ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:ccrud_13625Imported
OrganismiCorynebacterium crudilactisImported
Taxonomic identifieri1652495 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000076929 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 168tRNA-synt_1gInterPro annotationAdd BLAST105
Domaini293 – 477tRNA-synt_1_2InterPro annotationAdd BLAST185
Domaini803 – 914Anticodon_1InterPro annotationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi722 – 726"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK01869.

Family and domain databases

Gene3Di3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A172QWP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPSEGTTP LAFRYTPELA NKIEGEWQNY WTENGTFNAP NPVGDLAPAD
60 70 80 90 100
GKALPDDKLF VQDMFPYPSG AGLHVGHPLG YIATDVFARY NRMLGKNVLH
110 120 130 140 150
TLGYDSFGLP AEQYAIQTGT HPRATTMANI ENMKRQLEAL GLGHDSRRAV
160 170 180 190 200
ATTDPEFYKW TQWIFLQIFN SWFDVDQQKA RPISELIPLL ESGELKTKDG
210 220 230 240 250
ADYSALGDIE KQKAVDDYRL VYRSNSTVNW CPGLGTVLAN EEVTSDGRSE
260 270 280 290 300
RGNFPVFRKN LSQWMMRITA YSDRLIDDLE LLDWTDKVKS MQRNWIGRSR
310 320 330 340 350
GAEVDFSVEG ETVTVFTTRP DTLFGATYMV LAPEHELVDV LLSKAGTYDG
360 370 380 390 400
VDARWTNAQA TPAEAVAAYR ASIAAKSDLE RQENKEKTGV FVGVYATNPV
410 420 430 440 450
NGDQIPVFIA DYVLTGYGTG AIMAVPAHDE RDYEFATELG LPIVEVVSGG
460 470 480 490 500
NIAEAAFTES GAAVNSANDE GLDLNGLAKA EAVAQTIEWL EEKELGRGTI
510 520 530 540 550
QYKLRDWLFA RQRYWGEPFP IVYDENGQAH ALPASMLPVE LPEVEDYKPV
560 570 580 590 600
SFDPEDADSE PSPPLAKARE WVEVELDLGD GKKKYTRDTN VMPQWAGSSW
610 620 630 640 650
YQLRYIDPSN DEQFCNIENE RYWTGPRPET HGPNDPGGVD LYVGGVEHAV
660 670 680 690 700
LHLLYARFWH KVLFDLGHVS SKEPYRRLYN QGYIQAFAYT DSRGVYVAAD
710 720 730 740 750
EVEEKDGKFF YQGEEVNQEY GKMGKSLKNA VAPDDICNNF GADTLRVYEM
760 770 780 790 800
AMGPLDTSRP WATKDVVGAQ RFLQRMWRLI VDENTGEVLT RDMEALTDDD
810 820 830 840 850
NKQLHRTIAG VRDDYTNLRV NTVVAKLIEY VNYLTKTYPN TIPTGAVLPL
860 870 880 890 900
IVMASPVAPH IAEELWQKLG HDDTVTYEPF PTFEEKWLTD DEIELPVQVN
910 920 930 940 950
GKVRSRITVA ADASQEQVIE VALADEKVQE QLAGKNLIKQ IVVPGRMVNL

VVK
Length:953
Mass (Da):106,816
Last modified:September 7, 2016 - v1
Checksum:iCF65D0C5C69BA501
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP015622 Genomic DNA. Translation: ANE05135.1.
RefSeqiWP_066569083.1. NZ_CP015622.1.

Genome annotation databases

EnsemblBacteriaiANE05135; ANE05135; ccrud_13625.
KEGGiccjz:ccrud_13625.

Similar proteinsi

Entry informationi

Entry nameiA0A172QWP6_9CORY
AccessioniPrimary (citable) accession number: A0A172QWP6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: March 28, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported