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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ehrlichia ruminantium (Cowdria ruminantium)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei595ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:EHRUM2_03490Imported, EHRUM3_04270Imported
OrganismiEhrlichia ruminantium (Cowdria ruminantium)Imported
Taxonomic identifieri779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000092677 Componenti: Unassembled WGS sequence
  • UP000092731 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 163tRNA-synt_1gInterPro annotationAdd BLAST133
Domaini214 – 392tRNA-synt_1_2InterPro annotationAdd BLAST179
Domaini406 – 559tRNA-synt_1InterPro annotationAdd BLAST154
Domaini588 – 631tRNA-synt_1InterPro annotationAdd BLAST44
Domaini676 – 789Anticodon_1InterPro annotationAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 44"HIGH" regionUniRule annotationAdd BLAST11
Motifi592 – 596"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.6202 hits
3.90.740.101 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A170RSF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYNFKEVER DVQEKWDFTV NVKDVQCYVL EMFPYPSGNI HMGHLRNYTI
60 70 80 90 100
GDVIARYKRA CGLHVFHPIG WDAFGLPAEN AALSYNISPQ VWTRKNIDNM
110 120 130 140 150
RSQLKSIGLS YNWDKEFATC DAEYYKYEQE FFLDFLKYGL AYRKESLVNW
160 170 180 190 200
DPVDQTVLAN EQVIDGRGWR SGAIIEKRKL SQWFLKITDF AAELLDDLKL
210 220 230 240 250
LNQWPEKVKL MQERWIGKSE GVIIDFQIVG INEVLQVFTT SPHTLFGASF
260 270 280 290 300
IAVSFDHPIL KYINDVQLIQ LIDSFDRKDL IDDSSINTVE KFGINSGLVA
310 320 330 340 350
KHPLLDIDLP IYVANFVLMN YGTGAVFCCP AHDQRDFDFA KKYSLPIKQV
360 370 380 390 400
IFPEQNVNLE QEAYVGSGIM GCSEFLDGMT VDNAKKSMIK KLISLGICKK
410 420 430 440 450
QVYYRLHDWG ISRQRYWGCP IPIIYCKKCG IVPVNKKDLP ITLPEDIDFT
460 470 480 490 500
KSGNPLDNHP TWKYTKCPSC GADAKRETDT FDTFFESSWY FAAFCGVGKG
510 520 530 540 550
INKDLCNKLL PVDYYIGGIE HAVLHLLYSR FFCRALTRCG YFDIKEPFSS
560 570 580 590 600
LITQGMVCHS TYLDKYGNYL FPEDGKKMIQ EGKYVTVGRA EKMSKSKKNV
610 620 630 640 650
VHLDDIIDKY GADSARLFIL SDTPPERDIE WLDENIEGVS RYLNKLWKMI
660 670 680 690 700
VDYDQINLNF IFNDISNNAL EYRISVHKIL NDITNDLEFY RFNCAVAKFR
710 720 730 740 750
ELSNVISEMI RLSINHHVVS EAIYILIRVV EPFIPHIAEK LWQIVGGQGM
760 770 780 790 800
LCSQLWPKVD SQLLIKKNVN IVVQVNGKFI KAISVPNDID DDTLKSIALE
810 820 830
VAQRRIGNNS VKNIYIIPGR VINIVITKSS
Length:830
Mass (Da):95,392
Last modified:July 6, 2016 - v1
Checksum:iA5174C6493724224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BDDL01000041 Genomic DNA Translation: GAT77138.1
BDDM01000139 Genomic DNA Translation: GAT78213.1
RefSeqiWP_065432506.1, NZ_KZ208903.1

Genome annotation databases

EnsemblBacteriaiGAT75144; GAT75144; EHRUM4_03520
GAT77138; GAT77138; EHRUM2_03490
GAT78213; GAT78213; EHRUM3_04270

Similar proteinsi

Entry informationi

Entry nameiA0A170RSF8_EHRRU
AccessioniPrimary (citable) accession number: A0A170RSF8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: March 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported