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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium glutamicum (Brevibacterium saccharolyticum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei737ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:N24_3108Imported
OrganismiCorynebacterium glutamicum (Brevibacterium saccharolyticum)Imported
Taxonomic identifieri1718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

Subcellular locationi

A0A169SB67:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 180tRNA-synt_1gInterPro annotationAdd BLAST105
Domaini305 – 489tRNA-synt_1_2InterPro annotationAdd BLAST185
Domaini814 – 927Anticodon_1InterPro annotationAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi734 – 738"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A169SB67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCPVYLLHC LTMTNPSEGT TPLAFRYTPE LANKIEGEWQ NYWTENGTFN
60 70 80 90 100
APNPVGDLAP ADGKALPEDK LFVQDMFPYP SGAGLHVGHP LGYIATDVFA
110 120 130 140 150
RYNRMLGKNV LHTLGYDAFG LPAEQYAIQT GTHPRTTTMA NIENMKRQLG
160 170 180 190 200
ALGLGHDARR SVATTDPEFY KWTQWIFLQI FNSWFDAEQQ KARPISELIP
210 220 230 240 250
LLESGELKTK DGADYNELGD VEKQKAVDDY RLVYRSNSTV NWCPGLGTVL
260 270 280 290 300
ANEEVTADGR SERGNFPVFR KNLSQWMMRI TAYSDRLIDD LELLDWTEKV
310 320 330 340 350
KSMQRNWIGR SRGAEVDFTA EGETITVFTT RPDTLFGATY MVLAPEHELV
360 370 380 390 400
DVFLEKAGSY EGVDARWTNG QATPAEAVAA YRASIAAKSD LERQENKEKT
410 420 430 440 450
GVFLGVYATN PVNGDQIPVF IADYVLTGYG TGAIMAVPAH DDRDYEFATV
460 470 480 490 500
LGLPIKEVVA GGNIAEAAFT ESGEAVNSAN DNGLDINGLA KDDAVAQTIE
510 520 530 540 550
WLEEKELGRG TIQYKLRDWL FARQRYWGEP FPIVYDENGQ AHALPESMLP
560 570 580 590 600
VELPEVEDYK PVSFDPEDAD SEPSPPLAKA REWVEVELDL GDGKKKYTRD
610 620 630 640 650
TNVMPQWAGS SWYQLRYVDP SNDEQFCNID NERYWTGPRP ETHGPNDPGG
660 670 680 690 700
VDLYVGGVEH AVLHLLYARF WHKVLFDLGH VTSKEPYRRL YNQGYIQAFA
710 720 730 740 750
YTDSRGVYVP ADEVEEKDGK FFYQGEEVNQ EYGKMGKSLK NAVAPDDICN
760 770 780 790 800
NFGADTLRVY EMAMGPLDTS RPWATKDVVG AQRFLQRMWR LIVDENTGEV
810 820 830 840 850
LTRDEALTDD DNKQLHRTIA GVRDDYTNLR VNTVVAKLIE YVNYLTKTYP
860 870 880 890 900
NTIPADAVVP LIIMVSPIAP HIAEELWKKL GHDDTVTYEP FPTFEEKWLV
910 920 930 940 950
DDEIELPVQV NGKVRGRITV AADATQEQVI EAALADEKVQ EQISGKNLIK
960
QIVVPGRMVN LVVK
Length:964
Mass (Da):108,355
Last modified:July 6, 2016 - v1
Checksum:i3F65D733FACAA0E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP017369 Genomic DNA. Translation: BAU97370.1.

Similar proteinsi

Entry informationi

Entry nameiA0A169SB67_CORGT
AccessioniPrimary (citable) accession number: A0A169SB67
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: October 25, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation