Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydropteroate synthase

Gene

B4417_1819

Organism
Bacillus subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Cofactori

Mg2+UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (BMJ37_00700), Dihydropteroate synthase (folP), Dihydropteroate synthase (B4122_4479), Dihydropteroate synthase (KS08_00455), Dihydropteroate synthase (folP), Dihydropteroate synthase (B4417_1819), Dihydropteroate synthase (AX282_21440), Dihydropteroate synthase (A9D36_01505), Dihydropteroate synthase (SC09_Contig28orf00430)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processFolate biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthaseUniRule annotation (EC:2.5.1.15UniRule annotation)
Short name:
DHPSUniRule annotation
Alternative name(s):
Dihydropteroate pyrophosphorylaseUniRule annotation
Gene namesi
ORF Names:B4417_1819Imported
OrganismiBacillus subtilisImported
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000076589 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A164VK68
SMRiA0A164VK68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHPS family.UniRule annotation

Phylogenomic databases

PhylomeDBiA0A164VK68

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.201 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

A0A164VK68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQHTIDQTQ VIHTKPSALS YKEKTLVMGI LNVTPDSFSD GGKYDSLDKA
60 70 80 90 100
LLHAKEMIDD GAHIIDIGGE STRPGAECVS EDEEMSRVIP VIERITKELG
110 120 130 140 150
VPISVDTYKA SVADEAVKAG ASIINDIWGA KHDPKMASVA AEHNVPIVLM
160 170 180 190 200
HNRPERNYND LLPDMLSDLM ESVKIAVEAG VDEKNIILDP GIGFAKTYHD
210 220 230 240 250
NLAVMNKLEI FSGLGYPVLL ATSRKRFIGR VLDLPPEERA EGTGATVCLG
260 270 280
IQKGCDIVRV HDVKQIARMA KMMDAMLNKG GVHHG
Length:285
Mass (Da):31,002
Last modified:July 6, 2016 - v1
Checksum:iF2878DEC3D9000D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LJSM01000029 Genomic DNA Translation: KZD81934.1
RefSeqiWP_003242672.1, NZ_PISO01000007.1

Genome annotation databases

EnsemblBacteriaiKZD81934; KZD81934; B4417_1819
PATRICifig|1423.167.peg.3341

Similar proteinsi

Entry informationi

Entry nameiA0A164VK68_BACIU
AccessioniPrimary (citable) accession number: A0A164VK68
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: March 28, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported