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Protein

Dihydrofolate reductase

Gene

folA

Organism
Serratia symbiotica
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (folA), Dihydrofolate reductase (folA)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00158

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
Name:folAImported
ORF Names:STSPAZIEG_0350Imported
OrganismiSerratia symbioticaImported
Taxonomic identifieri138074 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000236289 Componenti: Chromosome 1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 158DHFRInterPro annotationAdd BLAST158

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.101 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A160SXA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISLISALAK KNVIGINNTI PWYLPKDLEW FKNNTLNKPI IMGYNTFTSI
60 70 80 90 100
GHPLPNRLNI VLSKNLRSES GVIFVNSLDN ALISAGNVDE VMIIGGECIY
110 120 130 140 150
NQFLIYTNRM YLTHININII GDTYFPIYTH YKWKTIFSKY YNINQINPYD

YYFEILERY
Length:159
Mass (Da):18,607
Last modified:July 6, 2016 - v1
Checksum:i46440D8EBF2A8621
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN890288 Genomic DNA Translation: CUR53702.1

Genome annotation databases

PATRICifig|138074.5.peg.336

Similar proteinsi

Entry informationi

Entry nameiA0A160SXA8_9GAMM
AccessioniPrimary (citable) accession number: A0A160SXA8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: April 25, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported