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Protein

Tyrosine-protein kinase receptor

Gene

Y1Q_0012601

Organism
Alligator mississippiensis (American alligator)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
ORF Names:Y1Q_0012601Imported
OrganismiAlligator mississippiensis (American alligator)Imported
Taxonomic identifieri8496 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator
Proteomesi
  • UP000050525 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei415 – 438HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500758479630 – 806Tyrosine-protein kinase receptorSequence analysisAdd BLAST777

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 280Ig-likeInterPro annotationAdd BLAST86
Domaini522 – 791Protein kinaseInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
IPR000372. LRRNT.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020455. Tyr_kin_neurotrophic_rcpt_2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
PfamiView protein in Pfam
PF07679. I-set. 2 hits.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
PRINTSiPR01939. NTKRECEPTOR.
PR01941. NTKRECEPTOR2.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A151M894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPWRRRWQG PGLWGLCCLV LGSWPGLLAC PTSCRCSAWR IWCTEPAPGV
60 70 80 90 100
VSFPRLERSA ERDNISDIYI ANQRKLESIN DNEVGLYIGL RNLTVVDSGL
110 120 130 140 150
KFVSRQAFLK NINLQYINLS RNKLSSLSKK PFRHLSLSDL ILVDNPFKCS
160 170 180 190 200
CDIMWIKIFQ ETKFSNAETQ DFYCINDNNK RIALMEMQIP NCGLPLANLS
210 220 230 240 250
SYNLTVLEGN SITVYCDATG VPLPNVSWAF TNLVSNHESD TSKNPASLTI
260 270 280 290 300
KNVSSKDNGL RISCLAENIV GEDQASVELT VFFAPNITFI ESPTSDHHWC
310 320 330 340 350
IPFTVKGNPK PTLQWFYEGA ILNESEYICT KIHVINQSEY HGCLQLDNPT
360 370 380 390 400
HLNNGAYTLL AKNEYGEDEK RVDAHFMSMP GDDYETTPND IGDTTNNSNQ
410 420 430 440 450
ITSTGFINTE NEDSITVYVV VGIAALVCTG LVIMLIILKF GRHSKFGMKG
460 470 480 490 500
PSSVISNDDD SASPLHHISN GSNTPSSSEG GPDAVIIGMT KIPVIENPQY
510 520 530 540 550
FGITNSQLKP DTFVQHIKRH NIVLKRELGE GAFGKVFLAE CYNLCPEQDK
560 570 580 590 600
ILVAVKTLKD ASDNARKDFH REAELLTNLQ HEHIVKFYGV CIEGDPLIMV
610 620 630 640 650
FEYMKHGDLN KFLRAHGPDA VLMAEGNRPA ELTQSQMLHI AQQIAAGMVY
660 670 680 690 700
LASQHFVHRD LATRNCLVGE NLLVKIGDFG MSRDVYSTDY YRVGGHTMLP
710 720 730 740 750
IRWMPPESIM YRKFTTESDV WSLGVVLWEI FTYGKQPWYQ LSNNEVIECI
760 770 780 790 800
TQGRVLQRPR TCPKEVYDLM LGCWQREPHM RLNIKEIHSL LLNLAKASPV

YLDILG
Length:806
Mass (Da):90,609
Last modified:June 8, 2016 - v1
Checksum:i5D7298B74E926B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKHW03006358 Genomic DNA. Translation: KYO20725.1.
RefSeqiXP_019333643.1. XM_019478098.1.

Genome annotation databases

GeneIDi102559730.

Similar proteinsi

Entry informationi

Entry nameiA0A151M894_ALLMI
AccessioniPrimary (citable) accession number: A0A151M894
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: November 22, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported