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Protein

Tyrosine-protein kinase receptor

Gene

Y1Q_0012601

Organism
Alligator mississippiensis (American alligator)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
ORF Names:Y1Q_0012601Imported
OrganismiAlligator mississippiensis (American alligator)Imported
Taxonomic identifieri8496 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator
Proteomesi
  • UP000050525 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei426 – 449HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500758483630 – 817Tyrosine-protein kinase receptorSequence analysisAdd BLAST788

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 280Ig-likeInterPro annotationAdd BLAST86
Domaini533 – 802Protein kinaseInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KOiK04360

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020455 Tyr_kin_neurotrophic_rcpt_2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01941 NTKRECEPTOR2
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

A0A151M889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPWRRRWQG PGLWGLCCLV LGSWPGLLAC PTSCRCSAWR IWCTEPAPGV
60 70 80 90 100
VSFPRLERSA ERDNISDIYI ANQRKLESIN DNEVGLYIGL RNLTVVDSGL
110 120 130 140 150
KFVSRQAFLK NINLQYINLS RNKLSSLSKK PFRHLSLSDL ILVDNPFKCS
160 170 180 190 200
CDIMWIKIFQ ETKFSNAETQ DFYCINDNNK RIALMEMQIP NCGLPLANLS
210 220 230 240 250
SYNLTVLEGN SITVYCDATG VPLPNVSWAF TNLVSNHESD TSKNPASLTI
260 270 280 290 300
KNVSSKDNGL RISCLAENIV GEDQASVELT VFFAPNITFI ESPTSDHHWC
310 320 330 340 350
IPFTVKGNPK PTLQWFYEGA ILNESEYICT KIHVINQSEY HGCLQLDNPT
360 370 380 390 400
HLNNGAYTLL AKNEYGEDEK RVDAHFMSMP GDGSGPILDP DLYDYETTPN
410 420 430 440 450
DIGDTTNNSN QITSTGFINT ENEDSITVYV VVGIAALVCT GLVIMLIILK
460 470 480 490 500
FGRHSKFGMK GPSSVISNDD DSASPLHHIS NGSNTPSSSE GGPDAVIIGM
510 520 530 540 550
TKIPVIENPQ YFGITNSQLK PDTFVQHIKR HNIVLKRELG EGAFGKVFLA
560 570 580 590 600
ECYNLCPEQD KILVAVKTLK DASDNARKDF HREAELLTNL QHEHIVKFYG
610 620 630 640 650
VCIEGDPLIM VFEYMKHGDL NKFLRAHGPD AVLMAEGNRP AELTQSQMLH
660 670 680 690 700
IAQQIAAGMV YLASQHFVHR DLATRNCLVG ENLLVKIGDF GMSRDVYSTD
710 720 730 740 750
YYRVGGHTML PIRWMPPESI MYRKFTTESD VWSLGVVLWE IFTYGKQPWY
760 770 780 790 800
QLSNNEVIEC ITQGRVLQRP RTCPKEVYDL MLGCWQREPH MRLNIKEIHS
810
LLLNLAKASP VYLDILG
Length:817
Mass (Da):91,737
Last modified:June 8, 2016 - v1
Checksum:iCB542A4D14482A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKHW03006358 Genomic DNA Translation: KYO20726.1
RefSeqiXP_006272132.1, XM_006272070.3

Genome annotation databases

GeneIDi102559730
KEGGiamj:102559730

Similar proteinsi

Entry informationi

Entry nameiA0A151M889_ALLMI
AccessioniPrimary (citable) accession number: A0A151M889
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: February 28, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health