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Protein

Purine nucleoside phosphorylase

Gene

PNP

Organism
Alligator mississippiensis (American alligator)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36PhosphateUniRule annotation1
Binding sitei67PhosphateUniRule annotation1
Binding sitei119Phosphate; via amide nitrogenUniRule annotation1
Binding sitei204Purine nucleosideUniRule annotation1
Binding sitei223PhosphateUniRule annotation1
Binding sitei246Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:PNPImported
ORF Names:Y1Q_0005030Imported
OrganismiAlligator mississippiensis (American alligator)Imported
Taxonomic identifieri8496 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator
Proteomesi
  • UP000050525 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 282PNP_UDP_1InterPro annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 89Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

PhylomeDBiA0A151M3M4.

Family and domain databases

InterProiView protein in InterPro
IPR000845. Nucleoside_phosphorylase_d.
IPR035994. Nucleoside_phosphorylase_sf.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiView protein in Pfam
PF01048. PNP_UDP_1. 1 hit.
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A151M3M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPEQRYTY EQYKETAEWL QANTKERPRV AVICGSGLGG LASLLKDQVV
60 70 80 90 100
IKYTDIPNFP QSTVVGHAGK LVFGRLSGKP CVVMQGRFHM YEGYPLWKVT
110 120 130 140 150
FPVRIFHLLG VETLIVTNAA GGLNPEYNVG DIMIIRDHIN MPGLAGINPL
160 170 180 190 200
VGPNEESFGV RFPPMSDAYD KDLRRLALAV ARDLGHAKSV HEGVYCSVGG
210 220 230 240 250
PSYETIAECR FLQRVGADAV GMSTVPEVIV ARHCGLRVFG FSLITNKAVL
260 270 280 290
DYTSQEKANH TEVLQAGSGS AKMLEKIVSE LVQRIESNNN LA
Length:292
Mass (Da):32,020
Last modified:June 8, 2016 - v1
Checksum:i6DC2F66BBC756062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKHW03006740 Genomic DNA. Translation: KYO19133.1.
RefSeqiXP_006266627.1. XM_006266565.3.

Genome annotation databases

GeneIDi102560242.

Similar proteinsi

Entry informationi

Entry nameiA0A151M3M4_ALLMI
AccessioniPrimary (citable) accession number: A0A151M3M4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: November 22, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported