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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Moorella mulderi DSM 14980
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateUniRule annotation1
Binding sitei38Substrate; via amide nitrogenUniRule annotation1
Binding sitei126Pyridoxal phosphateUniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei176Pyridoxal phosphateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Binding sitei207Pyridoxal phosphateUniRule annotation1
Binding sitei246Pyridoxal phosphateUniRule annotation1
Binding sitei364SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationSAAS annotationImported, Transferase
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotationImported
ORF Names:MOMUL_11470Imported
OrganismiMoorella mulderi DSM 14980Imported
Taxonomic identifieri1122241 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000075670 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 381Aminotran_1_2InterPro annotationAdd BLAST351

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 237Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019881 DAP-NH2Trfase_DapL_Desulfo
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03540 DapC_direct, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A151AY18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEARRIREL PPYLFARIEK KIEEAREQGV DIISLGIGDP DLPTPAHVID
60 70 80 90 100
KLVEQAHNPE NHRYPTSVGM LSFRQAVADW YRNLYNVDLD PRREVVTLIG
110 120 130 140 150
SKEGIAHISF CYVDPGDINL VPDPGYPVYH IGTLLAGGES YFMPLTAANG
160 170 180 190 200
FLPDLKEIPS DVARRAKLMF INYPNNPTGA VADLKFFQEV VEFAKNYDLI
210 220 230 240 250
VCHDAAYSEI TYDGYRAPSF LQTPGAKDVG IEFNSVSKPY NMTGWRLGWA
260 270 280 290 300
CGRADVIEAL GRLKSNIDSG AFQAVQYAGI AALTGPQDGL AEVRRIYQER
310 320 330 340 350
RDIIVEGLNS LGWQLEKPKA TFYVWAPVPK GYTSAGFAEM VLEKAGVIIT
360 370 380 390
PGNGYGNYGE GYFRIALTIS KERMQEAIER LRRALGKVEF
Length:390
Mass (Da):43,477
Last modified:June 8, 2016 - v1
Checksum:i6350B717B51DF660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LTBC01000003 Genomic DNA Translation: KYH32545.1
RefSeqiWP_062282650.1, NZ_LTBC01000003.1

Genome annotation databases

EnsemblBacteriaiKYH32545; KYH32545; MOMUL_11470
PATRICifig|1122241.3.peg.1206

Similar proteinsi

Entry informationi

Entry nameiA0A151AY18_9THEO
AccessioniPrimary (citable) accession number: A0A151AY18
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: March 28, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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