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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Thermobifida cellulosilytica TB100
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi94ZincUniRule annotation1
Metal bindingi97ZincUniRule annotation1
Metal bindingi167ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processOne-carbon metabolismUniRule annotationSAAS annotation
LigandGTP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
ORF Names:AC529_09545Imported
OrganismiThermobifida cellulosilytica TB100Imported
Taxonomic identifieri665004 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida
Proteomesi
  • UP000074382 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Homopolymer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 203GTP_cyclohydroIInterPro annotationAdd BLAST179

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit
PS00860 GTP_CYCLOHYDROL_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A147KI06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYEYRAGE IDAGLEPAGI DQPRIEKAVR EILLAIGEDP DRDGLVDTPA
60 70 80 90 100
RVARAFAEQY AGLHQRPEDV LTTVFEANHE EMVLVKDIEL YSTCEHHLVP
110 120 130 140 150
FYGVAHVGYI PNTDGRITGL SKLARLVDVY ARRPQVQERL TSQVADALME
160 170 180 190 200
HLEPRGVIVV VEAEHLCMTM RGVRKPGAKT VTSAVRGSFR ESDKTRAEAM

GLIMGHR
Length:207
Mass (Da):23,046
Last modified:June 8, 2016 - v1
Checksum:i52D36A35F1F7A4FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LGEM01000054 Genomic DNA Translation: KUP96934.1
RefSeqiWP_068756250.1, NZ_KQ950182.1

Genome annotation databases

EnsemblBacteriaiKUP96934; KUP96934; AC529_09545
PATRICifig|665004.4.peg.2385

Similar proteinsi

Entry informationi

Entry nameiA0A147KI06_9ACTN
AccessioniPrimary (citable) accession number: A0A147KI06
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: June 20, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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