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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacillus subterraneus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:GS3922_02055Imported
OrganismiGeobacillus subterraneusImported
Taxonomic identifieri129338 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000076226 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 170tRNA-synt_1gInterPro annotationAdd BLAST133
Domaini219 – 399tRNA-synt_1_2InterPro annotationAdd BLAST181
Domaini412 – 604tRNA-synt_1InterPro annotationAdd BLAST193
Domaini656 – 767Anticodon_1InterPro annotationAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili767 – 787Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi576 – 580"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK01869.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 2 hits.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A146CQX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNHREIEK KWQNYWEEQK TFRTPDESDK PKFYVLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT
110 120 130 140 150
QKNIDNFRRQ IKSLGFSYDW DREINTTDPN YYKWTQWIFL KLYEKGLAYI
160 170 180 190 200
DEVPVNWCPA LGTVLANEEV INGRSERGGH PVIRKPMRQW MLKITAYADR
210 220 230 240 250
LLEDLEELDW PESIKEMQRN WIGRSEGAEI EFAVDGHDES FTVFTTRPDT
260 270 280 290 300
LFGATYTVLA PEHPLVEKIT TPEQKQAVDA YLKEVQSKSD LERTDLAKEK
310 320 330 340 350
TGVFTGAYAV HPVTGARLPI WIADYVLMGY GTGAIMAVPA HDERDYEFAK
360 370 380 390 400
TFNLPIKEVV AGGNVENEPY TGDGEHIHSE FLNGLNKQEA IEKMIAWLEE
410 420 430 440 450
HGKGRKKVSY RLRDWLFSRQ RYWGEPIPVI HWEDGTMTTV PEEELPLVLP
460 470 480 490 500
KTDEIRPSGT GESPLANIEE WVNVVDPKTG KKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPHNDK QLADPEKLKQ WLPVDVYIGG AEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
LGIVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI VESHGADTLR
610 620 630 640 650
LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVTENGE LNPNIVDEPA
660 670 680 690 700
NDQLERVYHQ TVKKVTEDYE ALRFNTAISQ LMVFINEAYK AEQMKKEYME
710 720 730 740 750
GFVKLLSPVC PHIGEELWQK LGHTDTIAYE SWPAYDEAKL VEDVVEIVVQ
760 770 780 790 800
INGKVRAKLN VPADLSKEAL EERALADEKI KEQLQGKTVR KVIAVPGKLV

NIVAN
Length:805
Mass (Da):92,438
Last modified:June 8, 2016 - v1
Checksum:i4157EA18DBD5D0D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014342 Genomic DNA. Translation: AMX82551.1.
RefSeqiWP_063164956.1. NZ_LWHE01000010.1.

Genome annotation databases

EnsemblBacteriaiAMX82551; AMX82551; GS3922_02055.
GeneIDi32406641.
KEGGigsr:GS3922_02055.

Similar proteinsi

Entry informationi

Entry nameiA0A146CQX7_9BACI
AccessioniPrimary (citable) accession number: A0A146CQX7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: March 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported