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Protein

AMP phosphorylase

Gene

A0127_02550

Organism
Thermococcus peptonophilus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei203AMP; via amide nitrogenUniRule annotation1
Active sitei256Proton donorUniRule annotation1
Binding sitei264AMPUniRule annotation1
Binding sitei288AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 199AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
ORF Names:A0127_02550Imported
OrganismiThermococcus peptonophilusImported
Taxonomic identifieri53952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000073604 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 491PYNP_CInterPro annotationAdd BLAST68

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

KOiK18931

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A142CTM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKIRILDM FSGRYTVLIN EEDAKEAKLH PDDLVKIEAG KKAVYGSVAL
60 70 80 90 100
SNLVEKGEVG ISRDILDLHN FSEGETVSVI PAGTPESVRY IKKKMRGEKL
110 120 130 140 150
RKVEIESIVR DIVDRKLRDI EISSFVTALE INGLDMDEIA ALTIAMAETG
160 170 180 190 200
DMLDIDRKPI MDVHSIGGVP GNKTNILVVP IVAAAGLTIP KTSSRAITSA
210 220 230 240 250
AGTADVVEVF ANVSFSLDEI KRIVEKVGAC LVWGGALNLA PADDITIKAE
260 270 280 290 300
RALSIDPTGL MLASIMSKKY AMGSQYVLID IPTGKGVKVE TVEEARSLAR
310 320 330 340 350
DFIELGKRLG QYVEVAITYG GQPIGHTVGP ALEAREALSA LMTGRGPGSL
360 370 380 390 400
IEKATGLAGI LLEMGGVAPA GTGKKMAKEI LESGKAWEKM KEIIEAQGGD
410 420 430 440 450
SNIKPEEIPI GDKTYTFTAA TSGYVTAIDN RAITAIARAA GAPEDKGAGI
460 470 480 490 500
ELYVKVGEKV KEGDPLFTIH AEHEARLDQA IVLARRTEPI RIEGMVLQRI

GNI
Length:503
Mass (Da):53,789
Last modified:June 8, 2016 - v1
Checksum:i003EF0AB17906172
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014750 Genomic DNA Translation: AMQ18126.1
RefSeqiWP_062387581.1, NZ_CP014750.1

Genome annotation databases

EnsemblBacteriaiAMQ18126; AMQ18126; A0127_02550
GeneIDi27139390
KEGGitpep:A0127_02550

Similar proteinsi

Entry informationi

Entry nameiA0A142CTM4_9EURY
AccessioniPrimary (citable) accession number: A0A142CTM4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: March 28, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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