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Protein

Phosphodiesterase

Gene

Pde4d

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Pde4dImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3281. Pde4d.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

ExpressionAtlasiA0A140TAB1. baseline.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini386 – 627PDEase_IInterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118889.
OMAiQHEVEMP.

Family and domain databases

CDDicd00077. HDc. 1 hit.
Gene3Di1.10.1300.10. 1 hit.
InterProiView protein in InterPro
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR036971. PDEase_catalytic_dom_sf.
IPR023174. PDEase_CS.
PfamiView protein in Pfam
PF00233. PDEase_I. 1 hit.
PRINTSiPR00387. PDIESTERASE1.
PROSITEiView protein in PROSITE
PS00126. PDEASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A140TAB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASEETLHSCN DEEDPFRGME PYLVRRLSSR SIQLPPLAFR QLEQTDLRSE
60 70 80 90 100
SENIPRPTSL PLKILPLIAV TSADSTGFQD FCLTQETRST KPDTSKRGSG
110 120 130 140 150
MILQANFVHS QRRESFLYRS DSDYDLSPKS MSRNSSIASD IHGDDLIVTP
160 170 180 190 200
FAQVLASLRT VRNNFAALTN LQDRAPSKRS PMCNQPSINK ATITEEAYQK
210 220 230 240 250
LASETLEELD WCLDQLETLQ TRHSVSEMAS NKFKRMLNRE LTHLSEMSRS
260 270 280 290 300
GNQVSEYISN TFLDKQHEVE IPSPTQKEKE KKKRPMSQIS GVKKLMHSSS
310 320 330 340 350
LTNSCIPRFG VKTEQEDVLA KELEDVNKWG LHVFRIAELS GNRPLTVIMH
360 370 380 390 400
TIFQERDLLK TFKIPVDTLI TYLMTLEDHY HADVAYHNNI HAADVVQSTH
410 420 430 440 450
VLLSTPALEA VFTDLEILAA IFASAIHDVD HPGVSNQFLI NTNSELALMY
460 470 480 490 500
NDSSVLENHH LAVGFKLLQE ENCDIFQNLT KKQRQSLRKM AIDIVLATDM
510 520 530 540 550
SKHMNLLADL KTMVETKKVT SSGVLLLDNY SDRIQVLQNM VHCADLSNPT
560 570 580 590 600
KPLQLYRQWT DRIMEEFFRQ GDRERERGME ISPMCDKHNA SVEKSQVGFI
610 620 630 640 650
DYIVHPLWET WADLVHPDAQ DILDTLEDNR EWYQSTIPQS PSPAPDDQED
660 670 680 690 700
GRQGQTEKFQ FELTLEEDGE SDTEKDSGSQ VEEDTSCSDS KTLCTQDSES
710 720 730
TEIPLDEQVE EEAVAEEESQ PQTGVADDCC PDT
Length:733
Mass (Da):83,165
Last modified:May 11, 2016 - v1
Checksum:iEBBD49C158D7E7BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008048 Genomic DNA. No translation available.
AABR07008049 Genomic DNA. No translation available.
AABR07008050 Genomic DNA. No translation available.
AABR07008051 Genomic DNA. No translation available.
AABR07008052 Genomic DNA. No translation available.
AABR07008053 Genomic DNA. No translation available.
AABR07008054 Genomic DNA. No translation available.
AABR07008055 Genomic DNA. No translation available.
AABR07008056 Genomic DNA. No translation available.
AABR07008057 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000015138; ENSRNOP00000015138; ENSRNOG00000042536.

Similar proteinsi

Entry informationi

Entry nameiA0A140TAB1_RAT
AccessioniPrimary (citable) accession number: A0A140TAB1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: October 25, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported