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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Veillonella dispar
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processLipopolysaccharide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00358; UER00476.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotation
ORF Names:HMPREF1867_01775Imported
OrganismiVeillonella disparImported
Taxonomic identifieri39778 [NCBI]
Taxonomic lineageiBacteriaFirmicutesNegativicutesVeillonellalesVeillonellaceaeVeillonella
Proteomesi
  • UP000070492 Componenti: Unassembled WGS sequence

Subcellular locationi

A0A134BSP6:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02517. CMP-KDO-Synthetase. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00057. KdsB. 1 hit.
InterProiView protein in InterPro
IPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF02348. CTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A134BSP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGCVIPAR YGSTRLPGKP LADIAGKPMI ERVYERVSQA TKTECTIVAT
60 70 80 90 100
DDERVYSAVQ NFGGSVMMTD PNHPTGTDRL AEVANHYTDL DVIINVQGDE
110 120 130 140 150
PMIEPKLIDE LAQLFEEDPN LQMATVATPL LEDEYDEPSA VKVILNNRND
160 170 180 190 200
AMYFSRSLIP YPRHDFVRAP LKHIGIYAYR RDFLLNYAKM EPTPAEQTES
210 220 230 240
LEQLRALENG YTIRVILTDK RFIGVDTPED LARVNAIYEQ EEK
Length:243
Mass (Da):27,557
Last modified:June 8, 2016 - v1
Checksum:iD6ED38075165BE9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LSDO01000087 Genomic DNA. Translation: KXB82973.1.
RefSeqiWP_060924939.1. NZ_KQ960739.1.

Genome annotation databases

EnsemblBacteriaiKXB82973; KXB82973; HMPREF1867_01775.
PATRICifig|39778.3.peg.1748.

Similar proteinsi

Entry informationi

Entry nameiA0A134BSP6_9FIRM
AccessioniPrimary (citable) accession number: A0A134BSP6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: September 27, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported