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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Staphylococcus lugdunensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotationSAAS annotation
Gene namesi
Name:mscLUniRule annotation
ORF Names:HMPREF3225_01717Imported
OrganismiStaphylococcus lugdunensisImported
Taxonomic identifieri28035 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000070063 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 51HelicalUniRule annotationAdd BLAST31
Transmembranei71 – 92HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Interactioni

Subunit structurei

Homopentamer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.120, 1 hit
HAMAPiMF_00115 MscL, 1 hit
InterProiView protein in InterPro
IPR036019 Gated_MS_channel
IPR019823 Mechanosensitive_channel_CS
IPR001185 MS_channel
IPR037673 MSC/AndL
PANTHERiPTHR30266 PTHR30266, 2 hits
PfamiView protein in Pfam
PF01741 MscL, 1 hit
PRINTSiPR01264 MECHCHANNEL
SUPFAMiSSF81330 SSF81330, 1 hit
TIGRFAMsiTIGR00220 mscL, 1 hit
PROSITEiView protein in PROSITE
PS01327 MSCL, 1 hit

Sequencei

Sequence statusi: Complete.

A0A133Q3L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRKDIKVML KEFKEFALKG NVLDLAIAVV MGAAFNKIVT SLVTYIIMPL
60 70 80 90 100
IGKIFGSVDF AKDWEFWGIK YGLFIQSIID FLIVAFALFV FVKIANTLMK
110 120
KEEPEETIEE NTVLLTEIRD LLREKN
Length:126
Mass (Da):14,499
Last modified:June 8, 2016 - v1
Checksum:i4D00E414B77DE2BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LRQI01000075 Genomic DNA Translation: KXA37441.1

Genome annotation databases

EnsemblBacteriaiKXA37441; KXA37441; HMPREF3225_01717
PATRICifig|28035.7.peg.1739

Similar proteinsi

Entry informationi

Entry nameiA0A133Q3L0_STALU
AccessioniPrimary (citable) accession number: A0A133Q3L0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: April 25, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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