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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Legionella pneumophila
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
ORF Names:A1D14_13375Imported, ERS253249_00347Imported
OrganismiLegionella pneumophilaImported
Taxonomic identifieri446 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000074002 Componenti: Unassembled WGS sequence
  • UP000186644 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 48HelicalUniRule annotationAdd BLAST22
Transmembranei69 – 91HelicalUniRule annotationAdd BLAST23
Transmembranei97 – 114HelicalUniRule annotationAdd BLAST18
Transmembranei134 – 152HelicalUniRule annotationAdd BLAST19
Transmembranei172 – 193HelicalUniRule annotationAdd BLAST22
Transmembranei200 – 219HelicalUniRule annotationAdd BLAST20
Transmembranei239 – 256HelicalUniRule annotationAdd BLAST18
Transmembranei263 – 284HelicalUniRule annotationAdd BLAST22
Transmembranei290 – 311HelicalUniRule annotationAdd BLAST22
Transmembranei339 – 358HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Structurei

3D structure databases

SMRiA0A130QUI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A130QUI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYWLTQLLQ GQYHAFRVFQ YLTFRSILAS LTALIVGLLC GPLMIRWLRG
60 70 80 90 100
LQIGQMVRSD GPQTHLSKAG TPTMGGVLIL LAITVSCLLW CDLRQTSLWL
110 120 130 140 150
VLLVTLANGL VGWVDDYRKL VLKNSKGLPG RWKYFWQSVI ALVAVSYLYW
160 170 180 190 200
NASLPVHTQL TVPFFKTVTW DLGVFFPVLA YFVIVGSSNA VNLTDGLDGL
210 220 230 240 250
AIMPIVMVAG ALGVFAYASS NAVYSNYLGI PYVPNTGELT IFCSSIVGAG
260 270 280 290 300
LGFLWYNSYP AQVFMGDVGS LALGAALGIV AVVVRQELVL LIMGGLFVIE
310 320 330 340 350
TLSVILQVGY FKYSGGKRLF RMAPLHHHFE LKGWSEPKVI VRFWIITVVF
360
VLCGLATLKL R
Length:361
Mass (Da):39,854
Last modified:July 6, 2016 - v1
Checksum:i3330050916969E9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014760 Genomic DNA. Translation: APX20788.1.
FJKL01000002 Genomic DNA. Translation: CZN86121.1.
RefSeqiWP_014842671.1. NZ_LT906476.1.

Genome annotation databases

EnsemblBacteriaiCZM05633; CZM05633; ERS225379_01652.
CZN86121; CZN86121; ERS253249_00347.

Similar proteinsi

Entry informationi

Entry nameiA0A130QUI7_LEGPN
AccessioniPrimary (citable) accession number: A0A130QUI7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: November 22, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported