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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Pyrococcus kukulkanii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37TyrosineUniRule annotation1
Binding sitei168TyrosineUniRule annotation1
Binding sitei172TyrosineUniRule annotation1
Binding sitei175TyrosineUniRule annotation1
Binding sitei190TyrosineUniRule annotation1
Binding sitei254ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
ORF Names:TQ32_02405Imported
OrganismiPyrococcus kukulkaniiImported
Taxonomic identifieri1609559 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000070587 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi251 – 255"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.UniRule annotation

Phylogenomic databases

KOiK01866.

Family and domain databases

CDDicd00805. TyrRS_core. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_02009. Tyr_tRNA_synth_type4. 1 hit.
InterProiView protein in InterPro
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002307. Tyr-tRNA-ligase.
IPR023678. Tyr-tRNA-ligase_4.
IPR023617. Tyr-tRNA-ligase_arc/euk-type.
PfamiView protein in Pfam
PF00579. tRNA-synt_1b. 1 hit.
PIRSFiPIRSF006588. TyrRS_arch_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A127B8G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEDRINLV LKKPTEEVLT VENLRYLFEV GAPLQHYIGF EISGYIHLGT
60 70 80 90 100
GLMAGAKIAD FQKAGIKTRV FLADWHSWIN DKLGGDLETI QEVALKYFKV
110 120 130 140 150
GMERSIEVMG GDPKKVEFVL ASEILEKGDY WQTVIDISKN VTLSRVMRSI
160 170 180 190 200
TIMGRQMGEA IDFAKLIYPM MQVADIFYQG VTIAHAGMDQ RKAHVIAIEV
210 220 230 240 250
AQKLRYHPII HNGEKLKPVA VHHHLLLGLQ EPPKWPIESE EEFKEIKAQM
260 270 280 290 300
KMSKSKPYSA VFIHDSPEEI KQKLRKAFCP AREVRYNPVL DWAEYIIFRE
310 320 330 340 350
EPTEFTIHRP AKFGGDVTYT TFEELKKDFA EGKLHPLDLK NAVAEYLIDL
360 370
LEPVRKYFEK HPEPLELMQQ VRITR
Length:375
Mass (Da):43,233
Last modified:July 6, 2016 - v1
Checksum:i0EEB3F4F1F08BFBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP010835 Genomic DNA. Translation: AMM53467.1.
RefSeqiWP_068320651.1. NZ_CP010835.1.

Genome annotation databases

EnsemblBacteriaiAMM53467; AMM53467; TQ32_02405.
GeneIDi28490649.
KEGGipyc:TQ32_02405.
PATRICifig|1609559.3.peg.489.

Similar proteinsi

Entry informationi

Entry nameiA0A127B8G4_9EURY
AccessioniPrimary (citable) accession number: A0A127B8G4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: March 28, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported