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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Serratia rubidaea (Serratia marinorubra)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotationSAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi11Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi14Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi87Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei212S-adenosyl-L-methionineUniRule annotation1
Binding sitei241S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei262S-adenosyl-L-methionineUniRule annotation1
Binding sitei307S-adenosyl-L-methionineUniRule annotation1
Active sitei334PROSITE-ProRule annotation1
Active sitei334NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processrRNA processingUniRule annotationSAAS annotation
Ligand4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotationSAAS annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
ORF Names:AXX16_3530Imported
OrganismiSerratia rubidaea (Serratia marinorubra)Imported
Taxonomic identifieri61652 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000070291 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK03212.

Family and domain databases

HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiView protein in InterPro
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
PANTHERiPTHR11061. PTHR11061. 1 hit.
PfamiView protein in Pfam
PF05958. tRNA_U5-meth_tr. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiView protein in PROSITE
PS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A126VLN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCALYTAGS CRSCQWLEKP YPQQLADKQQ HLQALLAERE VGQWLPPVTG
60 70 80 90 100
ALSAFRNKAK MVVSGSVERP LLGMLHRDGT PVDLCACPLY PASFAPMFNV
110 120 130 140 150
LKTFIARAGL TPYNVARKRG ELKYLLLTES TSNGGVMLRF VLRSDSKLAQ
160 170 180 190 200
LRAALPWLQQ QLPQLQVISV NIQPVHMAIM EGEQEIILTE QQALEERFNQ
210 220 230 240 250
VPLYIRPQGF FQTNPQVASA LYAAARDWVR ELNIDSMWDL FCGVGGFGLH
260 270 280 290 300
CARPETRLTG IEISAEAIRC ARQSAATLGL QRVEFQALDS TRFATAEGDV
310 320 330 340 350
PQLVVVNPPR RGIGQALCDY LQRMAPDYLL YSSCNAQSMA QDIALLLGYR
360 370
IERVQLFDMF PHTAHYEVLT LLVREK
Length:376
Mass (Da):42,122
Last modified:June 8, 2016 - v1
Checksum:i1623DE651CEE1D4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014474 Genomic DNA. Translation: AML59221.1.
RefSeqiWP_061324486.1. NZ_CP014474.1.

Genome annotation databases

EnsemblBacteriaiAML59221; AML59221; AXX16_3530.
GeneIDi32373223.
KEGGisrz:AXX16_3530.
PATRICifig|61652.8.peg.3614.

Similar proteinsi

Entry informationi

Entry nameiA0A126VLN2_SERRU
AccessioniPrimary (citable) accession number: A0A126VLN2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: March 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported