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Protein

UvrABC system protein B

Gene

uvrB

Organism
Bacillus sp. LM 4-2
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotationSAAS annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
ORF Names:BsLM_3525Imported
OrganismiBacillus sp. LM 4-2Imported
Taxonomic identifieri1628753 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000033095 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A125UNA7.
SMRiA0A125UNA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 160Helicase ATP-bindingInterPro annotationAdd BLAST135
Domaini430 – 596Helicase C-terminalInterPro annotationAdd BLAST167
Domaini625 – 660UVRInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili246 – 284Sequence analysisAdd BLAST39
Coiled coili621 – 648Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92 – 115Beta-hairpinUniRule annotationAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK03702.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A125UNA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRFELVSK YQPQGDQPKA IEKLVKGIQE GKKHQTLLGA TGTGKTFTVS
60 70 80 90 100
NLIKEVNKPT LVIAHNKTLA GQLYSEFKEF FPNNAVEYFV SYYDYYQPEA
110 120 130 140 150
YVPQTDTFIE KDASINDEID KLRHSATSAL FERRDVIIIA SVSCIYGLGS
160 170 180 190 200
PEEYREMVVS LRTEMEIERN ELLRKLVDIQ YARNDIDFQR GTFRVRGDVV
210 220 230 240 250
EIFPASRDEH CVRVEFFGDE IERIREVDAL TGEILGDRDH VAIFPASHFV
260 270 280 290 300
TRAEKMEKAI QNIEKELEEQ LKVMHENGKL LEAQRLEQRT RYDLEMMREM
310 320 330 340 350
GFCSGIENYS RHLTLRPPGS TPYTLLDYFP DDFMIVVDES HVTIPQVRGM
360 370 380 390 400
FNGDQARKQV LVDHGFRLPS ALDNRPLRFE EFEKHMHNIV YVSATPGPYE
410 420 430 440 450
IEHTDEMVEQ IIRPTGLLDP LIDVRPIEGQ IDDLIGEIQA RIERNERVLV
460 470 480 490 500
TTLTKKMSED LTDYLKEIGI KVNYLHSEIK TLERIEIIRD LRLGKYDVLV
510 520 530 540 550
GINLLREGLD IPEVSLVAIL DADKEGFLRS ERSLIQTIGR AARNAEGRVI
560 570 580 590 600
MYADKITKSM EIAINETKRR REQQERFNEE HGITPKTINK EIRDVIRATV
610 620 630 640 650
AAEDKAEYKT KAAPKLSKMT KKERQKVVEQ MEHEMKEAAK ALDFERAAEL
660
RDLLLELKAE G
Length:661
Mass (Da):76,327
Last modified:April 13, 2016 - v1
Checksum:iA3C0A862A87F867C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011101 Genomic DNA. Translation: AKE25322.1.
RefSeqiWP_003243787.1. NZ_CP011101.1.

Genome annotation databases

EnsemblBacteriaiAKE25322; AKE25322; BsLM_3525.
KEGGibalm:BsLM_3525.
PATRICifig|1628753.6.peg.3546.

Similar proteinsi

Entry informationi

Entry nameiA0A125UNA7_9BACI
AccessioniPrimary (citable) accession number: A0A125UNA7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: November 22, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported