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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus sp. LM 4-2
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADUniRule annotation6
Nucleotide bindingi123 – 125NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:BsLM_2892Imported
OrganismiBacillus sp. LM 4-2Imported
Taxonomic identifieri1628753 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000033095 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A125UL95.
SMRiA0A125UL95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 147Ldh_1_NInterPro annotationAdd BLAST141
Domaini151 – 309Ldh_1_CInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

KOiK00024.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A125UL95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTRKKVSV IGAGFTGATT AFLIAQKELA DVVLVDIPQL ENPTKGKALD
60 70 80 90 100
MLEASPVQGF DAKITGTSNY EDTAGSDIVV ITAGIARKPG MSRDDLVSTN
110 120 130 140 150
EKIMRSVTQE IVKYSPDSII VVLTNPVDAM TYAVYKESGF PKERVIGQSG
160 170 180 190 200
VLDTARFRTF VAEELNLSVK DVTGFVLGGH GDDMVPLVRY SYAGGIPLET
210 220 230 240 250
LIPKERIDAI VERTRKGGGE IVNLLGNGSA YYAPAASLTE MVEAILKDQR
260 270 280 290 300
RVLPTIAYLE GEYGYEGIYL GVPTIVGGNG LEQIIELELT DYERAQLNKS
310
VESVKNVMKV LS
Length:312
Mass (Da):33,644
Last modified:April 13, 2016 - v1
Checksum:i656BA5BF5AA2D0CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011101 Genomic DNA. Translation: AKE24690.1.
RefSeqiWP_003229437.1. NZ_CP011101.1.

Genome annotation databases

EnsemblBacteriaiAKE24690; AKE24690; BsLM_2892.
KEGGibalm:BsLM_2892.
PATRICifig|1628753.6.peg.2918.

Similar proteinsi

Entry informationi

Entry nameiA0A125UL95_9BACI
AccessioniPrimary (citable) accession number: A0A125UL95
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: November 22, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported