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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnpA_1

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi490MagnesiumUniRule annotation1
Metal bindingi496MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationImported, RNA-bindingUniRule annotation, Transferase
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpA_1Imported
Synonyms:pnpUniRule annotation
ORF Names:ERS409327_00287Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A111AC96.
SMRiA0A111AC96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini626 – 694S1 motifInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR036345. ExoRNase_PH_dom2_sf.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR036612. KH_dom_type_1_sf.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom_sf.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR036456. PNPase_PH_RNA-bd_sf.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A111AC96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEKKVFKT EWAGRSLTIE TGQLAKQANG AVLVRYGDTV VLSTATASKE
60 70 80 90 100
PRDGDFFPLT VNYEEKMYAA GKIPGGFKKR EGRPGDEATL TARLIDRPIR
110 120 130 140 150
PLFPKGYRHD VQIMNIVLSA DPDCSPEMAA MIGSSMALSV SDIPFQGPIA
160 170 180 190 200
GVNVGYIDGK YVINPSVADK EISRLDLEVA GHKDAVNMVE AGASEITESE
210 220 230 240 250
MLEAIFFGHE EIKRLVAFQQ EIIDHIQPIK QEFVPVERDE DLVEKVKSLT
260 270 280 290 300
EDKGLKDTVL TFDKQQRDEN LDALKEEVVG HFLDEEDPEN ETLVKEVYAI
310 320 330 340 350
LNDLIKEEVR RLIADEKIRP DGRKVDEIRP LESEVGLLPR AHGSGLFTRG
360 370 380 390 400
QTQALSVLTL GALGDYQLID GLGPEVEKRF MHHYNFPNFS VGETGPVRAP
410 420 430 440 450
GRREIGHGAL GERALRYIIP DTQDFPYTIR IVSEVLESNG SSSQASICGS
460 470 480 490 500
TLALMDAGVP IKAPVAGIAM GLVTRDDSYT ILTDIQGMED ALGDMDFKVA
510 520 530 540 550
GTKDGITAIQ MDIKIDGLTR EVIEEALEQA RQGRLAIMDH MLHTIEQPRE
560 570 580 590 600
ELSAYAPKVV TMSINPDKIR DVIGPGGKKI NEIIDETGVK LDIEQDGTIF
610 620 630 640 650
IGAVDQAMIN RAKEIIEDIT REAEVGQVYH AKVKRIEKYG AFVELFPGKD
660 670 680 690 700
ALLHISQISQ ERINKVEDVL KIGDTIEVKI TEIDKQGRVN ASHKVLEQSK

N
Length:701
Mass (Da):77,444
Last modified:April 13, 2016 - v1
Checksum:iED6B9F1674F6ED20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FDON01000002 Genomic DNA. Translation: CVX78529.1.

Similar proteinsi

Entry informationi

Entry nameiA0A111AC96_STREE
AccessioniPrimary (citable) accession number: A0A111AC96
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: November 22, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)