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Protein

Ceramide very long chain fatty acid hydroxylase

Gene

AW171_hschr42197

Organism
Eremothecium sinecaudum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.UniRule annotation

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide very long chain fatty acid hydroxylaseUniRule annotation (EC:1.-.-.-UniRule annotation)
Gene namesi
ORF Names:AW171_hschr42197Imported
OrganismiEremothecium sinecaudumImported
Taxonomic identifieri45286 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei191 – 208HelicalSequence analysisAdd BLAST18
Transmembranei215 – 233HelicalSequence analysisAdd BLAST19
Transmembranei253 – 269HelicalSequence analysisAdd BLAST17
Transmembranei276 – 294HelicalSequence analysisAdd BLAST19
Transmembranei300 – 324HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 89Cytochrome b5 heme-bindingInterPro annotationAdd BLAST82

Sequence similaritiesi

Belongs to the sterol desaturase family. SCS7 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR036400. Cyt_B5-like_heme/steroid_sf.
IPR006694. Fatty_acid_hydroxylase.
IPR014430. Scs7.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF04116. FA_hydroxylase. 1 hit.
PIRSFiPIRSF005149. IPC-B_HD. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS50255. CYTOCHROME_B5_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A109UYS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEESKTLPL YPKALLQQHN SKNDCWVSVN YRKIYDATDF IRQNPSMSQA
60 70 80 90 100
ILEYAGKDIA QALKDKVFNK QTTAAYEILK DSNLVGYLAT EEEERKLLTN
110 120 130 140 150
EKHTVEVKLC DSDLTKFVKV LPSEEKLLVR TDFRNDLQKH KFLDLNKPLL
160 170 180 190 200
KQLWNSNFTR EFYIDQIHRP RHYGRGSAVL FGNFLEPLSK TAWWVVPMLW
210 220 230 240 250
YPLVFYFLAK AAKNLSAPLV IALFIFGIFV WTLVEYSLHR FLFHVDNHLP
260 270 280 290 300
ESTVVFTLHF LLHGFHHYLP MDKYRLVLPP ALFIVLCTPI YKLVFLMFPY
310 320 330 340 350
YWACAGFAGG VFGYIGYDMT HYFLHHHKLP PFMRKLKKYH LEHHYKNYEL
360 370
GYGVTSWFWD KVFGTYLGSD APVAKMKYQ
Length:379
Mass (Da):44,653
Last modified:April 13, 2016 - v1
Checksum:i4EDB4AEB2E9E0323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014244 Genomic DNA. Translation: AMD20310.1.
RefSeqiXP_017987306.1. XM_018132116.1.

Genome annotation databases

EnsemblFungiiAMD20310; AMD20310; AW171_hschr42197.
GeneIDi28723551.

Similar proteinsi

Entry informationi

Entry nameiA0A109UYS7_9SACH
AccessioniPrimary (citable) accession number: A0A109UYS7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: October 25, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)