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Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Methanobacteriaceae archaeon 41_258
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (purF)
  2. Phosphoribosylamine--glycine ligase (purD)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00125

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
GARSUniRule annotation
Glycinamide ribonucleotide synthetaseUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
Gene namesi
Name:purDUniRule annotation
ORF Names:XD44_1256Imported
OrganismiMethanobacteriaceae archaeon 41_258Imported
Taxonomic identifieri1635284 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceae

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 322ATP-graspInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili246 – 266Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the GARS family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.30.1490.201 hit
3.90.600.101 hit
HAMAPiMF_00138 GARS, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR020561 PRibGlycinamid_synth_ATP-grasp
IPR000115 PRibGlycinamide_synth
IPR020560 PRibGlycinamide_synth_C-dom
IPR037123 PRibGlycinamide_synth_C_sf
IPR020559 PRibGlycinamide_synth_CS
IPR020562 PRibGlycinamide_synth_N
IPR011054 Rudment_hybrid_motif
PfamiView protein in Pfam
PF01071 GARS_A, 1 hit
PF02843 GARS_C, 1 hit
PF02844 GARS_N, 1 hit
SMARTiView protein in SMART
SM01210 GARS_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR00877 purD, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00184 GARS, 1 hit

Sequencei

Sequence statusi: Complete.

A0A101DPK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVVGTGA REHAICRSLE DEAEIYSFMS NKNPGIARIV KGFKLGDETD
60 70 80 90 100
TEKVKSFAIE KNIDMAFIGP EAPLEKGIVD KLLAAEIEAV GPTAEAAKIE
110 120 130 140 150
TDKAFMRILF EKYRIPGSLQ YRVFDNYQEV SQFLDEFEGE AVVKPVGLTG
160 170 180 190 200
GKGVKIVGEH LKDNEEAKKY AKQVIEEKIG GQSRVVIEEK VTGEEFTLQA
210 220 230 240 250
FSDGEKLVPM PAVQDHPHAF EGDQGPITGG MGSYSDKNGL LPFLGKKEYD
260 270 280 290 300
QAVKIMRKTI EALNKEVGPY KGILYGQFML THDGPRIIEY NARFGDPEAM
310 320 330 340 350
NVLPLLETNM VNICEGIINT NLKTAKFKKL ATVCKYIVPK GYPEKGEAGK
360 370 380 390 400
PLEIDEKRIK SEGADIYYAS VNEKDGRIYT TSSRAVALVA LAEDIYTAEK
410 420 430
TCENATKFVK GDVYHRRDIG TRELIQKRIN HIKQIK
Length:436
Mass (Da):48,497
Last modified:April 13, 2016 - v1
Checksum:i01D510E249FF8641
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LGEU01000093 Genomic DNA Translation: KUK00677.1

Genome annotation databases

PATRICifig|1635284.3.peg.1364

Similar proteinsi

Entry informationi

Entry nameiA0A101DPK4_9EURY
AccessioniPrimary (citable) accession number: A0A101DPK4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: April 25, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)