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Protein

Dihydrofolate reductase

Gene

folA

Organism
Arsenophonus symbiont of Lipoptena fortisetosa
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (folA)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00158.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
Name:folAImported
ORF Names:AUT07_00400Imported
OrganismiArsenophonus symbiont of Lipoptena fortisetosaImported
Taxonomic identifieri634113 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeArsenophonus

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 160DHFRInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

KOiK00287.

Family and domain databases

CDDicd00209. DHFR. 1 hit.
Gene3Di3.40.430.10. 1 hit.
InterProiView protein in InterPro
IPR012259. DHFR.
IPR024072. DHFR-like_dom_sf.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
PANTHERiPTHR22778:SF16. PTHR22778:SF16. 1 hit.
PfamiView protein in Pfam
PF00186. DHFR_1. 1 hit.
PIRSFiPIRSF000194. DHFR. 1 hit.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiView protein in PROSITE
PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0X9WAQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISLIAAIS INKAIGFKNR IPWILSTDLA WFRKNTLNKP VVMGRITYES
60 70 80 90 100
IGNPLDQRLN IILSHTYLNN DNRIIWVHSI NEVLDITESM EETMIIGGGK
110 120 130 140 150
IYELFLPYAN KIYLTHVDIN IIGDVFFPNY KSTSWKTVFI EYHRADKKNT
160
HNYRFEILER LK
Length:162
Mass (Da):18,990
Last modified:April 13, 2016 - v1
Checksum:iD149C5960E2987BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013920 Genomic DNA. Translation: AMA64973.1.
RefSeqiWP_066283508.1. NZ_CP013920.1.

Genome annotation databases

EnsemblBacteriaiAMA64973; AMA64973; AUT07_00400.
KEGGiasy:AUT07_00400.
PATRICifig|634113.3.peg.385.

Similar proteinsi

Entry informationi

Entry nameiA0A0X9WAQ9_9GAMM
AccessioniPrimary (citable) accession number: A0A0X9WAQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: March 28, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)