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Protein

Hemagglutinin

Gene

HA

Organism
Influenza A virus (A/chicken/Anhui/A3348/2014(H9))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.SAAS annotation
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutininUniRule annotationSAAS annotation
Biological processClathrin- and caveolin-independent endocytosis of virus by hostSAAS annotation, Clathrin-mediated endocytosis of virus by hostSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
HemagglutininSAAS annotation
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/chicken/Anhui/A3348/2014(H9))Imported
Taxonomic identifieri1612909 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

  • Host apical cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2.UniRule annotationSAAS annotation

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza viruses hemagglutinin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di3.90.209.20. 1 hit.
HAMAPiMF_04072. INFV_HEMA. 1 hit.
InterProiView protein in InterPro
IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom_sf.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
PfamiView protein in Pfam
PF00509. Hemagglutinin. 1 hit.
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0A0X7YSW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTVSAITML LVATVSNADK ICIGYQSTNS AETVDTVTEN NVPVTHAKEL
60 70 80 90 100
LHTEHNGMLC ATSLGQPLIL DTCTIEGIIY GNPSCDLSLE GREWSYIVER
110 120 130 140 150
PSAVNGLCYP GNVENLEELR SLFSSARSYQ RIQIFPDTIW NVSYDGTSTA
160 170 180 190 200
CSGSFYKSMR WLTRKNGDYP IQDAQYTNNQ GKNILFMWGI NHPPTDTTQR
210 220 230 240 250
DLYTRTDTTT SVATEEINRV FKPLIGPRPL VNGLMGRIDY YWSVLKPGQT
260 270 280 290 300
LRIKSDGNLI APWFGHILSG ESHGRILKTD LKRGSCTVQC QTEKGGLNTT
310 320 330 340 350
LPFQNVSKYA FGNCSKYIGI KSLKLAVGLR NVPSRSSRGL FGAIAGFIEG
360 370 380 390 400
GWSGLVAGWY GFQHSNDQGV GMAADRDSTQ KAIDKITSKV NNIVDKMNKQ
410 420 430 440
YEIIDHEFSE VETRLNMINN KIDDQIQDLW AYNAELLVLL EYQKTLH
Length:447
Mass (Da):49,799
Last modified:April 13, 2016 - v1
Checksum:iD1BB67436838148B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei447Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP766643 Viral cRNA. Translation: AJS17114.1.

Similar proteinsi

Entry informationi

Entry nameiA0A0X7YSW9_9INFA
AccessioniPrimary (citable) accession number: A0A0X7YSW9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: December 20, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)