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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Legionella shakespearei DSM 23087
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
ORF Names:Lsha_0455Imported
OrganismiLegionella shakespearei DSM 23087Imported
Taxonomic identifieri1122169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000054600 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 48HelicalUniRule annotationAdd BLAST22
Transmembranei69 – 91HelicalUniRule annotationAdd BLAST23
Transmembranei97 – 114HelicalUniRule annotationAdd BLAST18
Transmembranei134 – 152HelicalUniRule annotationAdd BLAST19
Transmembranei164 – 185HelicalUniRule annotationAdd BLAST22
Transmembranei197 – 219HelicalUniRule annotationAdd BLAST23
Transmembranei239 – 256HelicalUniRule annotationAdd BLAST18
Transmembranei263 – 284HelicalUniRule annotationAdd BLAST22
Transmembranei290 – 311HelicalUniRule annotationAdd BLAST22
Transmembranei339 – 358HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0W0Z849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYWLTQLFQ GQYHALRVFQ YLTFRSILAS LTALMVGLLC GPLMIRWLRG
60 70 80 90 100
LQIGQMVRND GPQSHLSKAG TPTMGGVLIL LAITVSCLLW CDLKQSSLWL
110 120 130 140 150
VLLVTLGNGV VGWVDDYRKL VLKNSKGLPG RWKYFWQSVI ALIAVTYLYM
160 170 180 190 200
NASLPVHTQL TLPFLKSITL DLGILFPVLA YFVIVGSSNA VNLTDGLDGL
210 220 230 240 250
AIMPIVMVAG ALGVFAYVSS NAVYSNYLAI PFVPNTGELT IFCSSIVGAG
260 270 280 290 300
LGFLWYNSYP AQVFMGDVGS LALGAALGIV AIVVRQELVL LIMGGLFVIE
310 320 330 340 350
TISVILQVGY FKLSHGKRLF RMAPLHHHFE LKGWSEPKVI VRFWIITVVF
360
VLCGLATLKL R
Length:361
Mass (Da):39,746
Last modified:March 16, 2016 - v1
Checksum:i7D4D0F8B3349A18C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LNYW01000016 Genomic DNA. Translation: KTD65086.1.
RefSeqiWP_018578462.1. NZ_LNYW01000016.1.

Genome annotation databases

EnsemblBacteriaiKTD65086; KTD65086; Lsha_0455.
PATRICifig|1122169.6.peg.520.

Similar proteinsi

Entry informationi

Entry nameiA0A0W0Z849_9GAMM
AccessioniPrimary (citable) accession number: A0A0W0Z849
Entry historyiIntegrated into UniProtKB/TrEMBL: March 16, 2016
Last sequence update: March 16, 2016
Last modified: September 27, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported