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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

CACNA1F

Organism
Trichinella murrelli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1FImported
ORF Names:T05_15844Imported
OrganismiTrichinella murrelliImported
Taxonomic identifieri144512 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaEnopleaDorylaimiaTrichinellidaTrichinellidaeTrichinella
Proteomesi
  • UP000055048 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei146 – 165HelicalSequence analysisAdd BLAST20
Transmembranei243 – 264HelicalSequence analysisAdd BLAST22
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei336 – 355HelicalSequence analysisAdd BLAST20
Transmembranei417 – 438HelicalSequence analysisAdd BLAST22
Transmembranei450 – 472HelicalSequence analysisAdd BLAST23
Transmembranei581 – 597HelicalSequence analysisAdd BLAST17
Transmembranei617 – 642HelicalSequence analysisAdd BLAST26
Transmembranei649 – 667HelicalSequence analysisAdd BLAST19
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Transmembranei745 – 762HelicalSequence analysisAdd BLAST18
Transmembranei774 – 797HelicalSequence analysisAdd BLAST24
Transmembranei943 – 961HelicalSequence analysisAdd BLAST19
Transmembranei981 – 1005HelicalSequence analysisAdd BLAST25
Transmembranei1078 – 1097HelicalSequence analysisAdd BLAST20
Transmembranei1188 – 1215HelicalSequence analysisAdd BLAST28
Transmembranei1269 – 1287HelicalSequence analysisAdd BLAST19
Transmembranei1299 – 1319HelicalSequence analysisAdd BLAST21
Transmembranei1387 – 1412HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1549 – 1583Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili815 – 835Sequence analysisAdd BLAST21
Coiled coili1509 – 1529Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di1.20.120.3504 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 5 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0V0TY85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHAWKEYLCW HRESRPEQVV PSPIAEPRVA SIQTMIVRQV RHHARSEANF
60 70 80 90 100
NDDVNIGKEL SGNEAAALLH GDEARASRAD LWQQTLQAAV AAQTESSTTT
110 120 130 140 150
KKRQQQRKMQ RNVQQERPER SLLCLGLKNP IRKLFISIVE WKPFEWLILC
160 170 180 190 200
MICANCIALA VYQPFPAHDS DRKNAVLLCA IGKTFFDFVP AELRPAIDRQ
210 220 230 240 250
PGTAFQNRKH KLNPQPGQRT ATVAAVGHTG WGVGLFSEEQ VEYIFIVVFT
260 270 280 290 300
IECVMKVIAY GFLFHPGAYL RNGWNLLDFL IVVIGLISTA LSTLNIHGFD
310 320 330 340 350
VKALRAFRVL RPLRLVSGVP SLQVVLNSIL RAMVPLFHIA LLVLFVIIIY
360 370 380 390 400
AIIGLELFCG KLHKTCVDQW TGEHVPDPGP CGESHTSFHC DRSKNLVCTE
410 420 430 440 450
NHTWPGPNDG ITNFDNFGLA MLTVFQCISL EGWTDVMYWV NDSVGREWPW
460 470 480 490 500
IYFITLVILG SFFVLNLVLG VLSGEFSKER EKARARGLFQ KFREKQQLED
510 520 530 540 550
DLKGYLDWIT QAEDIDLVNE EDEEQEAMDR EEFGADGEGG EEGGSKEEFQ
560 570 580 590 600
RQSWFSMKIK RLKKLNRRCR RSCRRIVKSQ AFYWLVIVLV FLNTMVLTSE
610 620 630 640 650
HYGQPEWLDH FQEIANLFFV VLFTLEMFLK MYSLGFVNYF VALFNRFDCF
660 670 680 690 700
VVIGSILEFA LTFAGLMKPL GVSVLRSARL LRIFKVTKYW NSLRNLVASL
710 720 730 740 750
LNSLRSIASL LLLLFLFIVI FALLGMQVFG GKFNTIDPNM NKPRANFDTF
760 770 780 790 800
VQALLTVFQI LTGEDWNAVM YNGIAAFGGV HSIGVIVCIY FIVLFICGNY
810 820 830 840 850
ILLNVFLAIA VDNLADAESL TAAEKEEENK RANEADPEDD MVVKATADED
860 870 880 890 900
AVSVGQFHES GEVKLPFNEP TDAEDEHLAS GDDDQEREME NQSQFKPTAR
910 920 930 940 950
PHRQSELNLP KKTKPIPDAS SLFLFSSTNK VRIFCNKVIN HSYFTNSVLV
960 970 980 990 1000
CILVSSAMLA AEDPLQASSF RNEVPKFVLN YFDYFFTTVF TIEISLKVLV
1010 1020 1030 1040 1050
YGLILHKGSF CRNAFNLLDM LVVGVSLTSF GLKSGAISVV KILRVLRVLR
1060 1070 1080 1090 1100
PLRAINRAKG LKHVVQCVIV AVKTIGNIML VTFMLEFMFA IIGVQIFKGS
1110 1120 1130 1140 1150
FFRCTDRARL TAEECKGTFI EFEGGDVTRP HVRNREWTNY DFNFDNVQNA
1160 1170 1180 1190 1200
MVALFVVSTF EGWPDLLHVA MDSSDEGIGP QYNARVSVAI FFITFIVVIA
1210 1220 1230 1240 1250
FFMMNIFVGF VIVTFQSEGE REYENCELDK NQRKCIEFAL TAKPQRRYIP
1260 1270 1280 1290 1300
KNRFQYKIWW FVTSQPFEYA IFIIIILNTL ILGMKHYKSS AAFDEALDVL
1310 1320 1330 1340 1350
NLFFTTVFAL EFICKLFALT FKNYFGDAWN VFDFIIVLGS FIDIIYGKVS
1360 1370 1380 1390 1400
VPTGEAWQLI MLSCANTPAA MCDPESDDRG QPCGNDFAYP FFISFFMLCS
1410 1420 1430 1440 1450
FLIINLFVAV IMDNFDYLTR DWSILGPHHL DEFVRLWSEY DPDAKGRIKH
1460 1470 1480 1490 1500
LDVVTLLRKI SPPLGFGKLC PHRLACKRLV SMNMPLNSDG TVCFNSTLFA
1510 1520 1530 1540 1550
LVRTNLKIYT EVSSNIEEAN EQLRAVIKRI WKRTPQRLLD EIVPPSGRDD
1560 1570 1580 1590 1600
EITVGKFYAT YLIQDYFRRF KKRKEVEQKE TNMQGNITMS LQAGLRTLHE
1610 1620 1630 1640 1650
IGPEIKRAIS GNLETDWSKE FEEPQHRRDH SLFGTLVHAL QAHYKPFIEG
1660 1670 1680 1690 1700
NLTNPAYSNV NGDLKSQEGF LNSNPTNLYA TSRNGAVIHF SPTYVVEWTA
1710 1720 1730 1740 1750
LVLFDSDHDS SEHEMQERVR FVPRGSKPTG LSFEGSRWLP RKLSFRRTPI
1760 1770 1780 1790 1800
GGAAAVSNLQ QGNNKRLQFS NAIILDDSDP DSVLHSENVV DLTESGDDSK
1810 1820 1830 1840 1850
LSVSPPLELR DDAYYLDGID YNTWRPAPMG QGVRLRGRGN GRRKSRSMPL
1860 1870 1880 1890 1900
PHHEHQRNYA DVLVEKVLAD QGLGRYADPN LIRTTQLEIA EAYNMTEAQM
1910 1920 1930 1940 1950
HSAARSLMQR SPKYFEHMGG QRPADIKDFN QYSKTALLKP REINSSEEVD
1960
ISDDMNMFMS VV
Length:1,962
Mass (Da):223,272
Last modified:March 16, 2016 - v1
Checksum:iE1D23DBBC0FA1F97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JYDJ01000107 Genomic DNA Translation: KRX43957.1

Similar proteinsi

Entry informationi

Entry nameiA0A0V0TY85_9BILA
AccessioniPrimary (citable) accession number: A0A0V0TY85
Entry historyiIntegrated into UniProtKB/TrEMBL: March 16, 2016
Last sequence update: March 16, 2016
Last modified: March 28, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported