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Protein

Tubulin alpha chain

Gene

TBA8

Organism
Schistocephalus solidus (Tapeworm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
Name:TBA8Imported
ORF Names:TR144426Imported
OrganismiSchistocephalus solidus (Tapeworm)Imported
Taxonomic identifieri70667 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaDiphyllobothriideaDiphyllobothriidaeSchistocephalus

Subcellular locationi

  • Cytoplasmcytoskeleton SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 249TubulinInterPro annotationAdd BLAST198
Domaini251 – 396Tubulin_CInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR002452. Alpha_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0V0J5F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSAVREVV CIHIGQAGVQ IGNACWELFG LEHGIRPDGL YYDGYQPDDN
60 70 80 90 100
SFLTFYNETG HGKFVPRSII VDLEPTVVDE IRTGYYRQLF HPEQLISGKE
110 120 130 140 150
DAANNYARGF YTVGEQMIEL TMDRIRKVMD TCSMPQGFLI FHSLGGGTGS
160 170 180 190 200
GFASLLISRL SEDYRKRTKI ELVVYPAPRL ASAVVEPYNS VLTTHTCIEL
210 220 230 240 250
SEVVFLMDNE AVWEICRRNL DIRRPSFTNI NRILAQVISS LTAALRFDGQ
260 270 280 290 300
LNGDLTEFQT NLVPYPRIHF PLVTFAPIVA AEKAYHEQNS VDQITKACFE
310 320 330 340 350
PANSFVKVDP RNGKYMSVCL LYRGDVDPSS VNNATSAIKS SRSIQFVDWC
360 370 380 390 400
PTGFKVDINS QPTAAVPGGD LARVMRTCCM LANSTAIVEA FIRIDHKFDL
410 420 430 440
MFKKHAFVHW YVGEGLEEET FVTARQDLSA LEQDYEEVGY DTKG
Length:444
Mass (Da):49,846
Last modified:March 16, 2016 - v1
Checksum:i65B2A2722CFB093F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GEEE01002406 Transcribed RNA. Translation: JAP60819.1.

Similar proteinsi

Entry informationi

Entry nameiA0A0V0J5F4_SCHSO
AccessioniPrimary (citable) accession number: A0A0V0J5F4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 16, 2016
Last sequence update: March 16, 2016
Last modified: June 7, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)