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Protein

Cellular tumor antigen p53

Gene

TP53

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
Gene namesi
Name:TP53Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11998. TP53.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei373 – 392HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, Membrane, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141510.

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PeptideAtlasiA0A0U1RQC9.

Expressioni

Gene expression databases

ExpressionAtlasiA0A0U1RQC9. baseline and differential.

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 249P53InterPro annotationAdd BLAST194
Domaini280 – 318P53_tetramerInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000015092.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiView protein in Pfam
PF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS00348. P53. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0U1RQC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLMLSPDD IEQWFTEDPG PDEAPRMPEA APPVAPAPAA PTPAAPAPAP
60 70 80 90 100
SWPLSSSVPS QKTYQGSYGF RLGFLHSGTA KSVTCTYSPA LNKMFCQLAK
110 120 130 140 150
TCPVQLWVDS TPPPGTRVRA MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA
160 170 180 190 200
PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP YEPPEVGSDC TTIHYNYMCN
210 220 230 240 250
SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG RDRRTEEENL
260 270 280 290 300
RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQIRGRERFE
310 320 330 340 350
MFRELNEALE LKDAQAGKEP GGSRAHSREC QTLSPGDPDP PLSETFNLNI
360 370 380 390 400
CPYPAGKLEL LKLSPCPCLC RQVTLMSFLF FFLIFFYFRL YWGIIDPPKL
410
HTFKVCSVMI
Length:410
Mass (Da):45,884
Last modified:February 17, 2016 - v1
Checksum:i8743C2431EC8DE55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007421 Genomic DNA. No translation available.
AC087388 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000635293; ENSP00000488924; ENSG00000141510.

Similar proteinsi

Entry informationi

Entry nameiA0A0U1RQC9_HUMAN
AccessioniPrimary (citable) accession number: A0A0U1RQC9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: June 7, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported