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Protein

D-erythrose-4-phosphate dehydrogenase

Gene

epd

Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.UniRule annotationSAAS annotation

Catalytic activityi

D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH.UniRule annotationSAAS annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. D-erythrose-4-phosphate dehydrogenase (epd)
  2. Erythronate-4-phosphate dehydrogenase (pdxB)
  3. Phosphoserine aminotransferase (serC)
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei155NucleophileUniRule annotation1
Sitei182Activates thiol group during catalysisUniRule annotation1
Binding sitei200SubstrateUniRule annotation1
Binding sitei236SubstrateUniRule annotation1
Binding sitei318NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 13NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processPyridoxine biosynthesisUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00244; UER00309.

Names & Taxonomyi

Protein namesi
Recommended name:
D-erythrose-4-phosphate dehydrogenaseUniRule annotationSAAS annotation (EC:1.2.1.72UniRule annotationSAAS annotation)
Short name:
E4PDHUniRule annotation
Gene namesi
Name:epdUniRule annotationImported
Ordered Locus Names:YpsIP31758_0848Imported
OrganismiYersinia pseudotuberculosis serotype O:1b (strain IP 31758)Imported
Taxonomic identifieri349747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000002412 Componenti: Chromosome

Subcellular locationi

A0A0U1QX04:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0U1QX04.
SMRiA0A0U1QX04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 155Gp_dh_NInterPro annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 156Substrate bindingUniRule annotation3
Regioni213 – 214Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.UniRule annotation

Phylogenomic databases

KOiK03472.
OMAiNAKVLAW.

Family and domain databases

HAMAPiMF_01640. E4P_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR006422. E4P_DH_bac.
IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
PIRSFiPIRSF000149. GAP_DH. 1 hit.
PRINTSiPR00078. G3PDHDRGNASE.
SMARTiView protein in SMART
SM00846. Gp_dh_N. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01532. E4PD_g-proteo. 1 hit.
PROSITEiView protein in PROSITE
PS00071. GAPDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0U1QX04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRIAINGF GRIGRSVLRA LYESGRRAEI SVVAINELAS AEGMAHLLKY
60 70 80 90 100
DSSHGRFAWD VRQECDSLYV GDDIIRLIHQ SEIEQLPWSE LGIDVVLDCS
110 120 130 140 150
GVYGSREDGE AHVASGAKKV LFAHPGGHDL DATVVYGVNH QDLRAEHRIV
160 170 180 190 200
SNASCTTNCI IPIIQLLDIA YGIESGTVTT IHSSMNDQPV IDAYHQDLRR
210 220 230 240 250
TRAASQSIIP VDTKLAAGIT RIFPKFCDRF EAISVRVPTI NVTAIDLSVS
260 270 280 290 300
VTHPVGVAEV NQLLQKAARG AFRGIVDYTE LPLVSMDFNH DPHSAIVDGT
310 320 330
QTRVSGQHLI KTLVWCDNEW GFANRMLDTT LAMAKSGF
Length:338
Mass (Da):37,015
Last modified:February 17, 2016 - v1
Checksum:i5E0A54DCAD224E06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000720 Genomic DNA. Translation: ABS47146.1.
RefSeqiWP_002209964.1. NC_009708.1.

Genome annotation databases

EnsemblBacteriaiABS47146; ABS47146; YpsIP31758_0848.
KEGGiypi:YpsIP31758_0848.

Similar proteinsi

Entry informationi

Entry nameiA0A0U1QX04_YERP3
AccessioniPrimary (citable) accession number: A0A0U1QX04
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: October 25, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported