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Protein

Fatty acid oxidation complex subunit alpha

Gene

fadB

Organism
Salmonella enterica subsp. enterica serovar Bovismorbificans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.UniRule annotationSAAS annotation

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotationSAAS annotation
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotationSAAS annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotationSAAS annotation
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.UniRule annotationSAAS annotation
A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.UniRule annotationSAAS annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161Important for catalytic activityUniRule annotation1
Sitei190Important for catalytic activityUniRule annotation1
Binding sitei347SubstrateUniRule annotation1
Binding sitei375NAD; via amide nitrogenUniRule annotation1
Binding sitei394NADUniRule annotation1
Binding sitei458NADUniRule annotation1
Binding sitei480NADUniRule annotation1
Active sitei501For 3-hydroxyacyl-CoA dehydrogenase activityUniRule annotation1
Binding sitei504NADUniRule annotation1
Binding sitei551SubstrateUniRule annotation1
Binding sitei711SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi451 – 453NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation, LyaseUniRule annotationSAAS annotation, Multifunctional enzymeUniRule annotationSAAS annotation, OxidoreductaseUniRule annotationSAAS annotationImported
Biological processFatty acid metabolismUniRule annotationSAAS annotation, Lipid degradationUniRule annotationSAAS annotation, Lipid metabolism
LigandNADUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alphaUniRule annotation
Including the following 2 domains:
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimeraseUniRule annotation (EC:4.2.1.17UniRule annotation, EC:5.1.2.3UniRule annotation, EC:5.3.3.8UniRule annotation)
3-hydroxyacyl-CoA dehydrogenaseUniRule annotation (EC:1.1.1.35UniRule annotation)
Gene namesi
Name:fadBUniRule annotationImported
ORF Names:ERS008210_03398Imported
OrganismiSalmonella enterica subsp. enterica serovar BovismorbificansImported
Taxonomic identifieri58097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000039385 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini367 – 5453HCDH_NInterPro annotationAdd BLAST179
Domaini547 – 6433HCDHInterPro annotationAdd BLAST97
Domaini678 – 7403HCDHInterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 240Enoyl-CoA hydratase/isomeraseUniRule annotationAdd BLAST240
Regioni362 – 7803-hydroxyacyl-CoA dehydrogenaseUniRule annotationAdd BLAST419

Sequence similaritiesi

In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.UniRule annotationSAAS annotation
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01621 FadB, 1 hit
InterProiView protein in InterPro
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR012799 FadB
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 2 hits
PF02737 3HCDH_N, 1 hit
PF00378 ECH_1, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR02437 FadB, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0U0X0S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAERDHIG ISLIIYLHFI NTKYTLRFIW YDQITLWIQE TDMLYKGDTL
60 70 80 90 100
YLDWLEDGIA ELVFDAPGSV NKLDTATVAS LGQALEVLEK QHDLKGLLLR
110 120 130 140 150
SNKAAFIVGA DITEFLSLFL VPEEQLSQWL HFANSVFNRL EDLPVPTLAA
160 170 180 190 200
VNGYALGGGC ECVLATDYRL ATXXXXXXXX XPDLRIGLPE TKLGIMPGFG
210 220 230 240 250
GSVRLPRMLG ADSALEIIAA GKDVGAEHAL KIGLVDGVVK QEKLIEGAIA
260 270 280 290 300
VLRQAITGDL DWRAKRQPKL EPLKLSKIEA AMSFTIAKGM VAQTAGKHYP
310 320 330 340 350
APMTAVKTIE AAARFGREEA LNLENKSFVP LAHTNEARAL VGIFLNDQYV
360 370 380 390 400
KGKAKKLTKD IETPKQAAVL GAGIMGGGIA YQSAWKGVPV IMKDINDKSL
410 420 430 440 450
NLGMTEAAKL LNKQLERGKI DGLKLASVIS TIHPTLDYAG FDRVDVVVEA
460 470 480 490 500
VVENPKVKKA VLAETEQKVR PETVLASNTS TIPIGELASA LERPENFCGM
510 520 530 540 550
HFFNPVHRMP LVEIIRGEKS SDETIAKVVA WASKMGKTPI VVNDCPGFFV
560 570 580 590 600
NRVLFPYFAG FSQLLRDGAD FRKVDKVMEK QFGWPMGPAY LLDVVGIDTA
610 620 630 640 650
HHAQAVMAAG FPQRMQKEYR DAIDALFDAS RFGQKNGLGF WRYKEDRKGK
660 670 680 690 700
PKKEEDAAVD DLLASVSQPK RDFSDDEIIA RMMIPMINEV VRCLEEGIIA
710 720 730 740 750
SPAEADMALV YGLGFPPFHG GAFRWLDTQG SAKYLDMAQQ YQHLGPLYEV
760 770 780
PEGLHDKARH NEPYYPPVEP ARPVGSLKTA
Length:780
Mass (Da):85,845
Last modified:February 17, 2016 - v1
Checksum:i44E1DF0BCBF7985A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CSTI01000021 Genomic DNA Translation: CPR62125.1

Genome annotation databases

EnsemblBacteriaiCPR62125; CPR62125; ERS008210_03398

Similar proteinsi

Entry informationi

Entry nameiA0A0U0X0S3_SALET
AccessioniPrimary (citable) accession number: A0A0U0X0S3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: May 23, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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