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Protein

Dihydropteroate synthase

Gene

folP_2

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP), Dihydropteroate synthase (sulA), Dihydropteroate synthase (sulA), Dihydropteroate synthase (sulA), Dihydropteroate synthase (sulA), Dihydropteroate synthase (sulA), Dihydropteroate synthase (sulA), Dihydropteroate synthase (folP), Dihydropteroate synthase (sulA), Dihydropteroate synthase (sulA), Dihydropteroate synthase (folP), Dihydropteroate synthase (AZJ18_06075), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP), Dihydropteroate synthase (A4260_00800), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (sulA), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (sulA), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (sulA), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (sulA), Dihydropteroate synthase (folP), Dihydropteroate synthase (AWW74_05490), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_3), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (folP_2), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP_2)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processFolate biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthaseUniRule annotation (EC:2.5.1.15UniRule annotation)
Short name:
DHPSUniRule annotation
Alternative name(s):
Dihydropteroate pyrophosphorylaseUniRule annotation
Gene namesi
Name:folP_2Imported
ORF Names:ERS021733_04441Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000041439 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 271Pterin-bindingInterPro annotationAdd BLAST247

Sequence similaritiesi

Belongs to the DHPS family.UniRule annotation

Family and domain databases

CDDicd00739. DHPS. 1 hit.
Gene3Di3.20.20.20. 1 hit.
InterProiView protein in InterPro
IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
PfamiView protein in Pfam
PF00809. Pterin_bind. 1 hit.
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiView protein in PROSITE
PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0T8Q119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQHTIDQTQ VIHTKPSALA YKEKTLVMGI LNVTPDSFSD GGKYDSLDKA
60 70 80 90 100
LLHAEEMIND GAHIIDIGGE STRPGAECVS EDEEMSRVIP VIERITKELG
110 120 130 140 150
VPISVDTYKA SVADEAVKAG ASIINDIWGA KHDPKMASVA AEHNVPIVLM
160 170 180 190 200
HNRPERNYND LLPDMLSDLM ESVKIAVEAG VDEKNIILDP GIGFAKTYHD
210 220 230 240 250
NLAVMNKLEI LSGLGYPVLL ATSRKRFIGR VLDLPPEERA EGTGATVCLG
260 270 280
IQKGCDIVRV HDVKQIARMA KMMDAMLNKG GVHHG
Length:285
Mass (Da):30,952
Last modified:February 17, 2016 - v1
Checksum:i287CD5E226FBE30D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CLUP01000088 Genomic DNA. Translation: CJS69865.1.

Genome annotation databases

EnsemblBacteriaiCJS69865; CJS69865; ERS021733_04441.

Similar proteinsi

Entry informationi

Entry nameiA0A0T8Q119_STREE
AccessioniPrimary (citable) accession number: A0A0T8Q119
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: October 25, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported