Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Myocilin trabecular meshwork inducible glucocorticoid response isoform 1

Gene

MYOC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Myocilin trabecular meshwork inducible glucocorticoid response isoform 1Imported
Gene namesi
Name:MYOCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_500660828333 – 504Sequence analysisAdd BLAST472

Expressioni

Gene expression databases

ExpressionAtlasiA0A0S2Z421. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0S2Z421.
SMRiA0A0S2Z421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini244 – 503Olfactomedin-likeInterPro annotationAdd BLAST260

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 183Sequence analysisAdd BLAST70

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

OMAiRYKYSSM.
PhylomeDBiA0A0S2Z421.

Family and domain databases

InterProiView protein in InterPro
IPR031213. Myocilin.
IPR003112. Olfac-like_dom.
PANTHERiPTHR23192:SF48. PTHR23192:SF48. 1 hit.
PfamiView protein in Pfam
PF02191. OLF. 1 hit.
SMARTiView protein in SMART
SM00284. OLF. 1 hit.
PROSITEiView protein in PROSITE
PS51132. OLF. 1 hit.

Sequencei

Sequence statusi: Fragment.

A0A0S2Z421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFCARCCS FGPEMPAVQL LLLACLVWDV GARTAQLRKA NDQSGRCQYT
60 70 80 90 100
FSVASPNESS CPEQSQAMSV IHNLQRDSST QRLDLEATKA RLSSLESLLH
110 120 130 140 150
QLTLDQAARP QETQEGLQRE LGTLRRERDQ LETQTRELET AYSNLLRDKS
160 170 180 190 200
VLEEEKKRLR QENENLARRL ESSSQEVARL RRGQCPQTRD TARAVPPGSR
210 220 230 240 250
EVSTWNLDTL AFQELKSELT EVPASRILKE SPSGYLRSGE GDTGCGELVW
260 270 280 290 300
VGEPLTLRTA ETITGKYGVW MRDPKPTYPY TQETTWRIDT VGTDVRQVFE
310 320 330 340 350
YDLISQFMQG YPSKVHILPR PLESTGAVVY SGSLYFQGAE SRTVIRYELN
360 370 380 390 400
TETVKAEKEI PGAGYHGQFP YSWGGYTDID LAVDEAGLWV IYSTDEAKGA
410 420 430 440 450
IVLSKLNPEN LELEQTWETN IRKQSVANAF IICGTLYTVS SYTSADATVN
460 470 480 490 500
FAYDTGTGIS KTLTIPFKNR YKYSSMIDYN PLEKKLFAWD NLNMVTYDIK

LSKM
Length:504
Mass (Da):56,972
Last modified:February 17, 2016 - v1
Checksum:i9588C04F1D227623
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei504Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU178210 mRNA. Translation: ALQ33668.1.
RefSeqiNP_000252.1. NM_000261.1.
UniGeneiHs.436037.

Genome annotation databases

GeneIDi4653.
KEGGihsa:4653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU178210 mRNA. Translation: ALQ33668.1.
RefSeqiNP_000252.1. NM_000261.1.
UniGeneiHs.436037.

3D structure databases

ProteinModelPortaliA0A0S2Z421.
SMRiA0A0S2Z421.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4653.
KEGGihsa:4653.

Organism-specific databases

CTDi4653.

Phylogenomic databases

OMAiRYKYSSM.
PhylomeDBiA0A0S2Z421.

Gene expression databases

ExpressionAtlasiA0A0S2Z421. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR031213. Myocilin.
IPR003112. Olfac-like_dom.
PANTHERiPTHR23192:SF48. PTHR23192:SF48. 1 hit.
PfamiView protein in Pfam
PF02191. OLF. 1 hit.
SMARTiView protein in SMART
SM00284. OLF. 1 hit.
PROSITEiView protein in PROSITE
PS51132. OLF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0S2Z421_HUMAN
AccessioniPrimary (citable) accession number: A0A0S2Z421
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: June 7, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.