Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Myocilin trabecular meshwork inducible glucocorticoid response isoform 1

Gene

MYOC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Myocilin trabecular meshwork inducible glucocorticoid response isoform 1Imported
Gene namesi
Name:MYOCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_500660828333 – 504Sequence analysisAdd BLAST472

Proteomic databases

PRIDEiA0A0S2Z421

Expressioni

Gene expression databases

ExpressionAtlasiA0A0S2Z421 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0S2Z421
SMRiA0A0S2Z421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini244 – 503Olfactomedin-likeInterPro annotationAdd BLAST260

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 105Sequence analysisAdd BLAST21
Coiled coili114 – 183Sequence analysisAdd BLAST70

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

OMAiRYKYSSM
PhylomeDBiA0A0S2Z421

Family and domain databases

InterProiView protein in InterPro
IPR031213 Myocilin
IPR003112 Olfac-like_dom
PANTHERiPTHR23192:SF33 PTHR23192:SF33, 1 hit
PfamiView protein in Pfam
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A0S2Z421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFCARCCS FGPEMPAVQL LLLACLVWDV GARTAQLRKA NDQSGRCQYT
60 70 80 90 100
FSVASPNESS CPEQSQAMSV IHNLQRDSST QRLDLEATKA RLSSLESLLH
110 120 130 140 150
QLTLDQAARP QETQEGLQRE LGTLRRERDQ LETQTRELET AYSNLLRDKS
160 170 180 190 200
VLEEEKKRLR QENENLARRL ESSSQEVARL RRGQCPQTRD TARAVPPGSR
210 220 230 240 250
EVSTWNLDTL AFQELKSELT EVPASRILKE SPSGYLRSGE GDTGCGELVW
260 270 280 290 300
VGEPLTLRTA ETITGKYGVW MRDPKPTYPY TQETTWRIDT VGTDVRQVFE
310 320 330 340 350
YDLISQFMQG YPSKVHILPR PLESTGAVVY SGSLYFQGAE SRTVIRYELN
360 370 380 390 400
TETVKAEKEI PGAGYHGQFP YSWGGYTDID LAVDEAGLWV IYSTDEAKGA
410 420 430 440 450
IVLSKLNPEN LELEQTWETN IRKQSVANAF IICGTLYTVS SYTSADATVN
460 470 480 490 500
FAYDTGTGIS KTLTIPFKNR YKYSSMIDYN PLEKKLFAWD NLNMVTYDIK

LSKM
Length:504
Mass (Da):56,972
Last modified:February 17, 2016 - v1
Checksum:i9588C04F1D227623
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei504Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU178210 mRNA Translation: ALQ33668.1
RefSeqiNP_000252.1, NM_000261.1
UniGeneiHs.436037

Genome annotation databases

GeneIDi4653
KEGGihsa:4653

Similar proteinsi

Entry informationi

Entry nameiA0A0S2Z421_HUMAN
AccessioniPrimary (citable) accession number: A0A0S2Z421
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: May 23, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health