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UniProtKB - A0A0R4IZY3 (A0A0R4IZY3_MOUSE)

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Protein

Fibroblast growth factor receptor

Gene

Fgfr4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei609Proton acceptorUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1307965. betaKlotho-mediated ligand binding.
R-MMU-190322. FGFR4 ligand binding and activation.
R-MMU-5654228. Phospholipase C-mediated cascade, FGFR4.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr4Imported
ORF Names:mCG_3209Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:95525. Fgfr4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501062868617 – 799Fibroblast growth factor receptorSequence analysisAdd BLAST783

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Complete GO annotation...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 237Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST89
Domaini246 – 346Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST101
Domaini464 – 752Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923.
KOiK05095.
OMAiTHPQRME.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0R4IZY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLALLSI FQGTPALSLE ASEEMEQEPC LAPILEQQEQ VLTVALGQPV 
        60         70         80         90        100
RLCCGRTERG RHWYKEGSRL ASAGRVRGWR GRLEIASFLP EDAGRYLCLA 
       110        120        130        140        150
RGSMTVVHNL TLLMDDSLTS ISNDEDPKTL SSSSSGHVYP QQAPYWTHPQ 
       160        170        180        190        200
RMEKKLHAVP AGNTVKFRCP AAGNPMPTIH WLKDGQAFHG ENRIGGIRLR 
       210        220        230        240        250
HQHWSLVMES VVPSDRGTYT CLVENSLGSI RYSYLLDVLE RSPHRPILQA 
       260        270        280        290        300
GLPANTTAVV GSDVELLCKV YSDAQPHIQW LKHVVINGSS FGADGFPYVQ 
       310        320        330        340        350
VLKTTDINSS EVEVLYLRNV SAEDAGEYTC LAGNSIGLSY QSAWLTVLPE 
       360        370        380        390        400
EDLTWTTATP EARYTDIILY VSGSLVLLVL LLLAGVYHRQ VIRGHYSRQP 
       410        420        430        440        450
VTIQKLSRFP LARQFSLESR SSGKSSLSLV RGVRLSSSGP PLLTGLVNLD 
       460        470        480        490        500
LPLDPLWEFP RDRLVLGKPL GEGCFGQVVR AEAFGMDPSR PDQTSTVAVK 
       510        520        530        540        550
MLKDNASDKD LADLVSEMEV MKLIGRHKNI INLLGVCTQE GPLYVIVECA 
       560        570        580        590        600
AKGNLREFLR ARRPPGPDLS PDGPRSSEGP LSFPALVSCA YQVARGMQYL 
       610        620        630        640        650
ESRKCIHRDL AARNVLVTED DVMKIADFGL ARGVHHIDYY KKTSNGRLPV 
       660        670        680        690        700
KWMAPEALFD RVYTHQSDVW SFGILLWEIF TLGGSPYPGI PVEELFSLLR 
       710        720        730        740        750
EGHRMERPPN CPSELYGLMR ECWHAAPSQR PTFKQLVEAL DKVLLAVSEE 
       760        770        780        790 
YLDLRLTFGP FSPSNGDASS TCSSSDSVFS HDPLPLEPSP FPFSDSQTT
Length:799
Mass (Da):88,589
Last modified:January 20, 2016 - v1
Checksum:i7AFE17845FB4037E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123709 Genomic DNA. No translation available.
CH466546 Genomic DNA. Translation: EDL41174.1.
RefSeqiNP_032037.2. NM_008011.2.
UniGeneiMm.276715.

Genome annotation databases

EnsembliENSMUST00000005452; ENSMUSP00000005452; ENSMUSG00000005320.
GeneIDi14186.
KEGGimmu:14186.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA0A0R4IZY3_MOUSE
AccessioniPrimary (citable) accession number: A0A0R4IZY3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: July 5, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported