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Protein

Ribonuclease 3

Gene

rnc

Organism
Lactobacillus fabifermentans DSM 21115
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89MagnesiumUniRule annotation1
Active sitei93UniRule annotation1
Metal bindingi162MagnesiumUniRule annotation1
Active sitei165UniRule annotation1
Metal bindingi165MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
ORF Names:DY78_GL002942Imported
OrganismiLactobacillus fabifermentans DSM 21115Imported
Taxonomic identifieri1413187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000050920 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 176RNase IIIInterPro annotationAdd BLAST130
Domaini202 – 271DRBMInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.SAAS annotation

Family and domain databases

CDDicd00593. RIBOc. 1 hit.
Gene3Di1.10.1520.10. 1 hit.
HAMAPiMF_00104. RNase_III. 1 hit.
InterProiView protein in InterPro
IPR014720. dsRBD_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
IPR036389. RNase_III_sf.
PfamiView protein in Pfam
PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
SMARTiView protein in SMART
SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiView protein in PROSITE
PS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0R2NUS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIAREAYRT GIKTLFWWDI GRIYSIMLYC IDILKPERIA QMITELAAML
60 70 80 90 100
KERFGIVFNN EDLLAEAFTQ ASYVNEHQEQ NLKFYERVEF LGDAVLELAV
110 120 130 140 150
SEYLYKRYKD MPQGKLTRLR AAMVCEDSFA SFARECDFPK YIRLGKGEQK
160 170 180 190 200
AKAWERDSLL CDIFESFVGA LYLDQGREPV LKFVHQVIFP KLDEGRFDGV
210 220 230 240 250
FDYKTTLQEY LQRDGDVQID YNLIEQDGPA NERSYEIAVL ADGQKIGEGW
260 270
GHSKKEAEQS AARQAYSKLQ QKQD
Length:274
Mass (Da):31,864
Last modified:January 20, 2016 - v1
Checksum:iA9A7C3AB8AA7E741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AYGX02000070 Genomic DNA. Translation: KRO27693.1.

Genome annotation databases

EnsemblBacteriaiKRO27693; KRO27693; DY78_GL002942.

Similar proteinsi

Entry informationi

Entry nameiA0A0R2NUS7_9LACO
AccessioniPrimary (citable) accession number: A0A0R2NUS7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: October 25, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported