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Protein

Sodium channel protein

Gene

para

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:paraImported
Synonyms:Dvir\paraImported
ORF Names:Dvir_GJ19029Imported, GJ19029Imported
OrganismiDrosophila virilis (Fruit fly)Imported
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0015214. Dvir\para.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei145 – 172HelicalUniRule annotationAdd BLAST28
Transmembranei216 – 238HelicalUniRule annotationAdd BLAST23
Transmembranei250 – 268HelicalUniRule annotationAdd BLAST19
Transmembranei274 – 296HelicalUniRule annotationAdd BLAST23
Transmembranei406 – 428HelicalUniRule annotationAdd BLAST23
Transmembranei790 – 813HelicalUniRule annotationAdd BLAST24
Transmembranei834 – 851HelicalUniRule annotationAdd BLAST18
Transmembranei863 – 887HelicalUniRule annotationAdd BLAST25
Transmembranei918 – 940HelicalUniRule annotationAdd BLAST23
Transmembranei998 – 1019HelicalUniRule annotationAdd BLAST22
Transmembranei1310 – 1332HelicalUniRule annotationAdd BLAST23
Transmembranei1338 – 1364HelicalUniRule annotationAdd BLAST27
Transmembranei1385 – 1416HelicalUniRule annotationAdd BLAST32
Transmembranei1503 – 1529HelicalUniRule annotationAdd BLAST27
Transmembranei1592 – 1610HelicalUniRule annotationAdd BLAST19
Transmembranei1622 – 1641HelicalUniRule annotationAdd BLAST20
Transmembranei1653 – 1672HelicalUniRule annotationAdd BLAST20
Transmembranei1716 – 1739HelicalUniRule annotationAdd BLAST24
Transmembranei1802 – 1825HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1846 – 1881EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili24 – 44Sequence analysisAdd BLAST21
Coiled coili432 – 467Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
PfamiView protein in Pfam
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
PRINTSiPR00170. NACHANNEL.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0Q9WLZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV
60 70 80 90 100
PQYGRKKKQK EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST
110 120 130 140 150
PLEDIDPYYS NILTFVVVSK GKDIFRFSAS KAMWLLDPFN PIRRVAIYIL
160 170 180 190 200
VHPLFSLFII TTILVNCILM IMPTTPTVES TEVIFTGIYT FESAVKVMAR
210 220 230 240 250
GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR TFRVLRALKT
260 270 280 290 300
VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
310 320 330 340 350
CIKKFPLDGS WGNLTDENWD YHNRNSSNWY SEDDGISFPL CGNISGAGQC
360 370 380 390 400
DDDYVCLQGF GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA
410 420 430 440 450
AGPWHMLFFI VIIFLGSFYL VNLILAIVAM SYDELQKKAE EEEAAEEEAI
460 470 480 490 500
REAEEAAAAK AAKLEERANA HAQAAADAAA AEEAALHPEM AKSPTYSCIS
510 520 530 540 550
YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP TTAHQATKVR
560 570 580 590 600
KVSTYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD DSNAVTPMSE
610 620 630 640 650
ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK
660 670 680 690 700
ESKLRNRNTR NQSVGATNGG TTCLDTNHKV EHRDYEIGLE CTDEAGKIKH
710 720 730 740 750
HDNPFIEPVQ TQTVVDMKDV MVLNDIIEQA AGRHSRASDR GVSVYYFPTE
760 770 780 790 800
DDDEDGPTLK DRALEVILKG IDVFCVWDCC WVWLKFQEWV SLIVFDPFVE
810 820 830 840 850
LFITLCIVVN TMFMAMDHHD MNKEMERVLK AGNYFFTATF AIEATMKLMA
860 870 880 890 900
MSPKYYFQEG WNIFDFIIVA LSLLELGLEG VQGLSVLRSF RLLRVFKLAK
910 920 930 940 950
SWPTLNLLIS IMGRTMGALG NLTFVLCIII FIFAVMGMQL FGKNYHDHKD
960 970 980 990 1000
RFPDGDLPRW NFTDFMHSFM IVFRVLCGEW IESMWDCMYV GDVSCIPFFL
1010 1020 1030 1040 1050
ATVVIGNLVV LNLFLALLLS NFGSSSLSAP TADNDTNKIA EAFNRIGRFK
1060 1070 1080 1090 1100
SWVKRNVADC FKLIRNKLTN QISDQPSGER INQISWIWSE EHGDNELELG
1110 1120 1130 1140 1150
HDEILADGLI KKGIKEQTQL EVAIGDGMEF TIHGDMKNNK PKKSKYLNNA
1160 1170 1180 1190 1200
TDDDTASINS YGSHKNRPFK DESHKGSAET MEGEEKRDAS KEDLGLDEEL
1210 1220 1230 1240 1250
DEEGECEEGP LDGDIIIHAN DEDILDEYPA DCCPDSYYKK FPILAGDEDS
1260 1270 1280 1290 1300
PFWQGWGNLR LKTFQLIENK YFETAVITMI LMSSLALALE DVHLPQRPIL
1310 1320 1330 1340 1350
QDILYYMDRI FTVIFFLEML IKWLALGFKV YFTNAWCWLD FVIVMVSLIN
1360 1370 1380 1390 1400
FVASLVGAGG IQAFKTMRTL RALRPLRAMS RMQGMRVVVN ALVQAIPSIF
1410 1420 1430 1440 1450
NVLLVCLIFW LIFAIMGVQL FAGKYFKCED LNGTKLSHEI IPNRNACESE
1460 1470 1480 1490 1500
NYTWVNSAMN FDHVGNAYLC LFQVATFKGW IQIMNDAIDS REVDKQPIRE
1510 1520 1530 1540 1550
TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED
1560 1570 1580 1590 1600
QKKYYNAMKK MGSKKPLKAI PRPRWRPQAI VFEIVTDKKF DIIIMLFIGL
1610 1620 1630 1640 1650
NMFTMTLDRY DASDTYNAVL DYLNAIFVVI FSSECLLKIF ALRYHYFIEP
1660 1670 1680 1690 1700
WNLFDVVVVI LSILGLVLSD IIEKYFVSPT LLRVVRVAKV GRVLRLVKGA
1710 1720 1730 1740 1750
KGIRTLLFAL AMSLPALFNI CLLLFLVMFI FAIFGMSFFM HVKEKSGIND
1760 1770 1780 1790 1800
VYNFKTFGQS MILLFQMSTS AGWDGVLDAI INEEACDPPD NDKGYPGNCG
1810 1820 1830 1840 1850
SATVGITFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM
1860 1870 1880 1890 1900
YYEIWQQFDP EGTQYIRYDQ LSEFLDVLEP PLQIHKPNKY KIISMDIPIC
1910 1920 1930 1940 1950
RGDLMYCVDI LDALTKDFFA RKGNPIEETG EIGEIAARPD TEGYEPVSST
1960 1970 1980 1990 2000
LWRQREEYCA RLIQHAWRKH KTRAEAGGGD PDADAANDMD PDPAAGDDAP
2010 2020 2030 2040 2050
DDNAAADDDP DAAGANGGHD PAADGAAVDP ANDPKSIVNS PMDGGGGSPG
2060 2070 2080 2090
GQSAGSGGSA GRQTAVLVES DGFVTKNGHK VVIHSRSPSI TSRTADV
Length:2,097
Mass (Da):236,064
Last modified:January 20, 2016 - v1
Checksum:i4574B39EB3D701A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940651 Genomic DNA. Translation: KRF82127.1.
RefSeqiXP_015026549.1. XM_015171063.1.

Genome annotation databases

GeneIDi6631799.

Similar proteinsi

Entry informationi

Entry nameiA0A0Q9WLZ4_DROVI
AccessioniPrimary (citable) accession number: A0A0Q9WLZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: December 20, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported