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Protein

Pantothenate synthetase

Gene

panC

Organism
Caulobacter sp. Root655
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42Proton donorUniRule annotation1
Binding sitei66Beta-alanineUniRule annotation1
Binding sitei66PantoateUniRule annotation1
Binding sitei158PantoateUniRule annotation1
Binding sitei181ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 42ATPUniRule annotation8
Nucleotide bindingi152 – 155ATPUniRule annotation4
Nucleotide bindingi189 – 192ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
ORF Names:ASD79_11845Imported
OrganismiCaulobacter sp. Root655Imported
Taxonomic identifieri1736578 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000051604 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiView protein in InterPro
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiView protein in Pfam
PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0Q8FJ91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPAPKIVR TVADLRDQVR TWKTAGERVA LIPTMGALHE GHLSLIKLGQ
60 70 80 90 100
VHAQRTVASI FVNPRQFAPH EDFDSYPRGE ARDVDLLAEV GCDLLFAPNV
110 120 130 140 150
AEMYAPGFST AIEVSGVSEP LEGAARPQFF GGVATVVTKL LIQAQAEVAL
160 170 180 190 200
FGEKDYQQLQ VIKRVVRDLD LPVEIIGAPT ARAPDGLALS SRNAYLSAEE
210 220 230 240 250
RAAAVALPTA LKAAAQAVAA GGRVDEAEAA GKAALTAAGF GQIDYLEVRE
260 270 280
ASDLSRLGPG PINDANARIL VAAWLGRTRL IDNMAV
Length:286
Mass (Da):30,333
Last modified:January 20, 2016 - v1
Checksum:iDF4DD8DDA0EB1B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LMHC01000023 Genomic DNA. Translation: KRA59372.1.
RefSeqiWP_056723475.1. NZ_LMHC01000023.1.

Genome annotation databases

EnsemblBacteriaiKRA59372; KRA59372; ASD79_11845.

Similar proteinsi

Entry informationi

Entry nameiA0A0Q8FJ91_9CAUL
AccessioniPrimary (citable) accession number: A0A0Q8FJ91
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: March 28, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported