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Protein

Ribosomal RNA large subunit methyltransferase I

Gene

rlmI

Organism
Escherichia coli TW10598
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.UniRule annotationSAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1962) in 23S rRNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, RNA-bindingUniRule annotationSAAS annotation, Transferase
Biological processrRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase IUniRule annotationSAAS annotation (EC:2.1.1.191UniRule annotation)
Alternative name(s):
23S rRNA m5C1962 methyltransferaseUniRule annotation
rRNA (cytosine-C(5)-)-methyltransferase RlmIUniRule annotation
Gene namesi
Name:rlmIUniRule annotationImported
ORF Names:TW10598_1049Imported
OrganismiEscherichia coli TW10598Imported
Taxonomic identifieri913091 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

A0A0P8APK3:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0P8APK3.
SMRiA0A0P8APK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81PUAInterPro annotationAdd BLAST80

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmI family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
HAMAPiMF_01857. 23SrRNA_methyltr_I. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR036974. PUA_sf.
IPR023542. rRNA_lsu_MeTfrase_I.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF10672. Methyltrans_SAM. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0P8APK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRLVLAKG REKSLLRRHP WVFSGAVARM EGKASLGETI DIVDHQGKWL
60 70 80 90 100
ARGAYSPASQ IRARVWTFDP SESIDIAFFS RRLQQAQKWR DWLAQKDGLD
110 120 130 140 150
SYRLIAGESD GLPGITIDRF GNFLVLQLLS AGAEYQRAAL ISALQTLYPE
160 170 180 190 200
CSIYDRSDVA VRKKEGMELT QGPVTGELPP ALLPIEEHGM KLLVDIQHGH
210 220 230 240 250
KTGYYLDQRD SRLATRRYVE NKRVLNCFSY TGGFAVSALM GGCSQVVSVD
260 270 280 290 300
TSQEALDIAR QNVELNKLDL SKAEFVRDDV FKLLRTYRDR GEKFDVIVMD
310 320 330 340 350
PPKFVENKSQ LMGACRGYKD INMLAIQLLN EGGILLTFSC SGLMTSDLFQ
360 370 380 390
KIIADAAIDA GRDVQFIEQF RQAADHPVIA TYPEGLYLKG FACRVM
Length:396
Mass (Da):44,357
Last modified:January 20, 2016 - v1
Checksum:i09C5ECEB62733D8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AELA02000001 Genomic DNA. Translation: KPQ46764.1.
RefSeqiWP_000116297.1. NZ_CM007915.1.

Similar proteinsi

Entry informationi

Entry nameiA0A0P8APK3_ECOLX
AccessioniPrimary (citable) accession number: A0A0P8APK3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: October 25, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported